Browsing by Subject "unfolded protein response"

Now showing items 1-3 of 3

    • ER Proteostasis Control of Neuronal Physiology and Synaptic Function 
      Martínez, Gabriela; Khatiwada, Sanjeev; Costa-Mattioli, Mauro; Hetz Flores, Claudio (Elsevier Ltd, 2018)
      © 2018 Elsevier Ltd Neuronal proteostasis is maintained by the dynamic integration of different processes that regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic reticulum (ER) ...
    • Glucose Metabolism: A Sweet Relief of Alzheimer's Disease 
      Durán Aniotz, Claudia; Hetz Flores, Claudio (2016)
      Patients and individuals at risk for Alzheimer's disease show reduced glucose metabolism in the brain. A new study takes advantage of a fly model of Alzheimer's disease to demonstrate that enhancing glucose uptake in neurons ...
    • Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis 
      Gupta, S.; Read, D. E.; Deepti, A.; Cawley, K.; Gupta, A.; Oommen, D.; Verfaillie, T.; Matus, S.; Smith, M. A.; Mott, J. L.; Agostinis, P.; Hetz Flores, Claudio; Samali, A. (2012)
      Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be ...