Now showing items 41-55 of 55

    • Hernández Ríos, Patricia; Pussinen, Pirkko J.; Vernal Astudillo, Rolando; Hernández, Marcela (Frontiers Media SA, 2017)
      Oxidative stress is involved in the pathogenesis of a variety of inflammatory disorders. Apical periodontitis (AP) usually results in the formation of an osteolytic apical lesion (AL) caused by the immune response to ...
    • Carvajal, Paola; Vernal Astudillo, Rolando; Reinero, Daniela; Malheiros, Zilson; Stewart, Bernal; Pannuti, Claudio Mendes; Romito, Giuseppe Alexandre (Sociedade Brasileira de Pesquisa Odontologica, 2020)
      The epidemiological data on gingivitis and periodontitis in Latin America are scarce, as the majority of the Latin American studies have analyzed probing depth instead of clinical attachment loss. Reported data have shown ...
    • Monasterio Ocares, María Carolina; Castillo, F.; García, K.; Álvarez, C.; Rojas, L.; Núñez, C.; Flores, G.; Díaz Guzmán, Walter; Vernal Astudillo, Rolando (2016)
    • Vernal Astudillo, Rolando; Dezerega Piwonka, Andrea; Dutzan Muñoz, Nicolás; Chaparro, Alejandra; León Berríos, Rubén; Chandía Espinosa, Sabrita; Silva, A.; Gamonal Aravena, Jorge Antonio (BLACKWELL, 2006-05)
      OBJECTIVES: The cytokine receptor activator of nuclear factor kappa B-ligand (RANKL) has been involved in both the physiological and pathological regulation of osteoclast life span and bone metabolism. Periapical granuloma ...
    • Álvarez, Carla; Suliman, Salwa; Almarhoumi, Rawan; Vega, María Elena; Rojas, Carolina; Monasterio, Gustavo; Galindo, Mario; Vernal Astudillo, Rolando; Kantarci, Alpdogan (Nature, 2020)
      The alveolar bone resorption is a distinctive feature of periodontitis progression and determinant for tooth loss. Regulatory T lymphocytes (Tregs) display immuno-suppressive mechanisms and tissue repairing functions, which ...
    • Alvarez, Carla; Rojas Rojas, Carolina Andrea; Rojas, Leticia; Cafferata, Emilio A.; Monasterio, Gustavo; Vernal Astudillo, Rolando (Hindawi Ltd, 2018)
      Periodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated ...
    • Vernal Astudillo, Rolando; Velásquez, E.; Gamonal Aravena, Jorge Antonio (2007)
      Propósito. La osteoartritis temporomandibular es una enfermedad articular degenerativa, caracterizada por la destrucción del cartílago y hueso articular consecutiva a la respuesta inflamatoria e inmune desarrollada. En ...
    • Rojas, Leticia; Melgar Rodríguez, Samanta; Díaz Zúñiga, Jaime; Alvarez, Carla; Monasterio, Gustavo; Rojas, Carolina; Carvajal, Paola; Vernal Astudillo, Rolando (Elsevier Ltd, 2018)
      Objective: In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Mixed infection with the different A. actinomycetemcomitans serotypes is frequent in periodontitis ...
    • Díaz Zúñiga, Jaime; Yáñez Figueroa, Juan Pablo; Álvarez, Carla; Melgar Rodríguez, Samanta; Hernández Ríos, Emma; Sanz, Mariano; Vernal Astudillo, Rolando (2014)
      Aim: Different serotypes of Aggregatibacter actinomycetemcomitans have been described based on the lipopolysaccharide (LPS)-O-polysaccharide antigenicity. In turn, a distinct effect of A. actinomycetemcomitans serotypes ...
    • Restaino Bianchi, Carmen Gloria; Chaparro, Alejandra; Valenzuela, María Antonieta; Kettlun, Ana María; Vernal Astudillo, Rolando; Silva, A.; Puente Piccardo, Javier; Jaque, M. P.; León Berríos, Rubén; Gamonal Aravena, Jorge Antonio (2007)
      OBJECTIVE: Neutrophils play a crucial role in the defense of invading bacteria by releasing biologically active molecules. The response of peripheral blood neutrophils was studied in periodontitis-affected patients and in ...
    • Rojas García, Carolina; Campos Mora, Mauricio; Cárcamo, Ignacio; Villalón, Natalia; Elhusseiny, Ahmed; Contreras Kallens, Pamina; Refisch, Aarón; Gálvez Jirón, Felipe; Emparán, Ivana; Montoya Riveros, Andro; Vernal Astudillo, Rolando; Pino Lagos, Karina (Wiley, 2020)
      T regulatory (Treg) cells have a major role in the maintenance of immune tolerance against self and foreign antigens through the control of harmful inflammation. Treg cells exert immunosuppressive function by several ...
    • Monasterio, G.; Castillo, F.; Rojas, L.; Cafferata, E.; Álvarez, C.; Carvajal, P.; Núñez, C.; Flores, G.; Díaz, W.; Vernal Astudillo, Rolando (Wiley, 2018-08)
      It is well accepted that the presence of cytokines belonging to the Th1/Th17/Th22 axis of immuno-inflammatory response in the joint environment, such as IL-1, IL-17 and IL-22, respectively, are associated with pathogenesis ...
    • Vernal Astudillo, Rolando; García Sanz, José A. (2008)
      In addition to the T helper 1 (Th1) and Th2 lymphocyte subsets, two new subpopulations Th17 and regulatory T (Treg) cells have recently been described. Th17 cells, which produce high levels of interleukin (IL)-17, ...
    • Soto, Cristopher; Bugueño Valdebenito, Isaac; Hoare Teuche, Anilei; González, S.; Vengas Díaz, Darna; Melgar Rodríguez, Samanta; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio; Quest, Andrew F. G.; Pérez Donoso, José; Bravo Rodríguez, Denisse (Wiley Blackwell, 2016)
      Background and ObjectivePorphyromonas gingivalis infection induces apoptosis inhibition in gingival epithelial cells; however, it is not fully understood which bacterial effectors are involved in this process. The aim of ...
    • Díaz Guerra, Eva; Vernal Astudillo, Rolando; Cantero, Walter; Müllner, Ernst; García Sanz, José (Bentham Science Publishers B.V., 2009)
      Recent data from a series of laboratories has pinpointed the relevant role of translation control on the regulation of gene expression. In particular, an analysis of T cell activation has led to demonstrate that during ...