Browsing by Subject "Rab5"

Now showing items 1-5 of 5

    • Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation 
      Silva, Patricio; Soto, Nicolás; Díaz, Jorge; Mendoza, Pablo; Díaz, Natalia; Quest, Andrew F. G.; Torres Gómez, Vicente (Elsevier, 2015)
      The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of ...
    • Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis 
      Silva, Patricio; Mendoza, Pablo; Rivas, Solange; Díaz, Jorge; Moraga, Carolina; Quest, Andrew F. G.; Torres, V. A. (Oncotarget, 2016)
      Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that hypoxia alters endosome dynamics in tumor ...
    • Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex ... 
      Reyes Rojas, Montserrat; Peña Oyarzún, Daniel; Silva, Patricio; Venegas, Sebastián; Criollo Céspedes, Alfredo; Torres Gómez, Vicente (Wiley, 2020)
      Potentially malignant lesions, commonly referred to as dysplasia, are associated with malignant transformation by mechanisms that remain unclear. We recently reported that increased Wnt secretion promotes the nuclear ...
    • The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis 
      Torres, Pedro; Díaz Jara, Jorge; Arce, Maximiliano; Silva, Patricio; Mendoza, Pablo; Lois, Pablo; Molina Berríos, Alfredo Enrique; Owen, Gareth I.; Palma Alvarado, Verónica; Torres Gómez, Vicente (Federation of American Societies for Experimental Biology, 2017)
      Saliva is a key factor that contributes to the high efficiency of wound healing in the oral mucosa. This is not only attributed to physical cues but also to the presence of specific peptides in the saliva, such as histatins. ...
    • Wnt/beta-Catenin Signaling in Oral Carcinogenesis 
      Reyes Rojas, Montserrat; Flores Lillo, Tania; Betancur, Diego; Peña Oyarzún, Daniel; Torres Gómez, Vicente (MDPI, 2020)
      Oral carcinogenesis is a complex and multifactorial process that involves cumulative genetic and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair and defective cell death. At the ...