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Authordc.contributor.authorLastra, Olga C. 
Authordc.contributor.authorLemus Gutiérrez, Igor es_CL
Authordc.contributor.authorSánchez, Hugo J. es_CL
Authordc.contributor.authorPérez, Renato F. es_CL
Admission datedc.date.accessioned2007-06-04T15:40:00Z
Available datedc.date.available2007-06-04T15:40:00Z
Publication datedc.date.issued2003-09-19
Cita de ítemdc.identifier.citationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 33 (2): 175-180 SEP 19 2003en
Identifierdc.identifier.issn0731-7085
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120425
Abstractdc.description.abstractDevelopment and validation of an analytical UV derivative spectrophotometric method to quantify Losartan potassium used as a single active principle in pharmaceutical forms were done. Pharmacopeias have not yet provided an official method for its quantification. A study was carried out of all the parameters established by USP XXIV to validate an analytical method for a solid pharmaceutical form, i.e. linearity, range, accuracy, precision and specificity. All these parameters were found in accordance with the acceptance criteria of Comite de Guias Oficiales de Validacion de la Direccion General de Control de Insumos para la Salud de Mexico. Based on the spectrophotometric characteristics of Losartan potassium, a signal at 234 nm of the first derivative spectrum (ID234) was found adequate for quantification. The linearity between signal ID234 and concentration of Losartan potassium in the range of 4.00-6.00 mg l(-1) in aqueous solutions presents a square correlation coefficient (r(2)) of 0.9938. The mean recovery percentage was 100.7 + 1.1% and the precision expressed as relative standard deviation (R.S.D.) 0.88%. In addition, the proposed method is simple, easy to apply, low-cost, does not use polluting reagents and requires relatively inexpensive instruments. Then, it is a good alternative to existing methods for determining Losartan potassium in tablets provided that the pharmaceutical dosage form does not contain hydrochlorothiazide as second drug.en
Lenguagedc.language.isoenen
Publisherdc.publisherPERGAMON-ELSEVIER SCIENCE LTDen
Keywordsdc.subjectLIQUID-CHROMATOGRAPHYen
Títulodc.titleDevelopment and validation of an UV derivative spectrophotometric determination of Losartan potassium in tabletsen
Document typedc.typeArtículo de revistaen


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