Show simple item record

Authordc.contributor.authorYáñez Soto, Claudia 
Authordc.contributor.authorLápez Alarcón, Camilo Ignacio es_CL
Authordc.contributor.authorCamargo Grandón, Rodrigo es_CL
Authordc.contributor.authorValenzuela, V. es_CL
Authordc.contributor.authorSquella Serrano, Juan es_CL
Authordc.contributor.authorNúñez Vergara, Luis es_CL
Admission datedc.date.accessioned2008-06-06T16:32:42Z
Available datedc.date.available2008-06-06T16:32:42Z
Publication datedc.date.issued2004-05-01
Cita de ítemdc.identifier.citationBIOORGANIC & MEDICINAL CHEMISTRY 12(9):2459-2468en
Identifierdc.identifier.issn0968-0896
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/120443
Abstractdc.description.abstractA series of eight commercial C-4 substituted 1,4-dihydropyridines and other synthesized related compounds were tested for direct potential scavenger effect towards alkylperoxyl radicals and ABTS radical cation in aqueous Britton-Robinson buffer pH 7.4. A direct quenching radical species was established. The tested 1,4-dihydropyridines were 8.3-fold more reactive towards alkylperoxyl radicals than ABTS cation radical, expressed by their corresponding kinetic rate constants. Furthermore, NPD a photolyte of nifedipine and the C-4 unsubstituted 1,4-DHP were the most reactive derivatives towards alkylperoxyl radicals. The pyridine derivative was confirmed by GOMS technique as the final product of reaction. In consequence, the reduction of alkylperoxyl and ABTS radicals by 1,4-dihydropyridines involved an electron transfer process. Also, the participation of the hydrogen of the 1-position appears as relevant on the reactivity. Results of reactivity were compared with Trolox.en
Lenguagedc.language.isoenen
Publisherdc.publisherPERGAMON-ELSEVIER SCIENCEen
Keywordsdc.subject1,4-dihydropyridinesen
Títulodc.titleStructural effects on the reactivity 1,4-dihydropyridines with alkylperoxyl radicals and ABTS radical cationen
Document typedc.typeArtículo de revistaen


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record