Simultaneous determination of melatonin and pyridoxine in tablets by gas chromatography-mass spectrometry
Author | dc.contributor.author | Núñez Vergara, Luis | es_CL |
Author | dc.contributor.author | Squella Serrano, Juan | es_CL |
Author | dc.contributor.author | Sturm Schaub, Juan | es_CL |
Author | dc.contributor.author | Báez Guerrero, Hernán | es_CL |
Author | dc.contributor.author | Camargo Grandón, Rodrigo | |
Admission date | dc.date.accessioned | 2008-06-12T12:30:09Z | |
Available date | dc.date.available | 2008-06-12T12:30:09Z | |
Publication date | dc.date.issued | 2001-12 | |
Cita de ítem | dc.identifier.citation | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 26(5-6):929-938 | en |
Identifier | dc.identifier.issn | 0731-7085 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120457 | |
Abstract | dc.description.abstract | A gas chroma tographic-mass spectrometric (GC-MS) method for the qualitative and quantitative determination of melatonin plus pyridoxine commercial tablets is described. Melatonin and pyridoxine were simultaneously determined by GC-MS after extraction from ground tablets with methanol and derivatization with N-methyl-N-N-trimethlyisilyltrifluoroacetamide (MSTFA). The mass chromatograms were generated using 232 m/z ion for melatonin and 280 m/z ion for pyridoxine, respectively. Splitless injection offers good reproducibility with a standard deviation of 2%. The developed method was applied to analyze the melatonin and pyridoxine content from two different tablet formulations. Also, recovery, detection and quantification limits are reported. | en |
Lenguage | dc.language.iso | en | en |
Publisher | dc.publisher | PERGAMON-ELSEVIER SCIENCE | en |
Keywords | dc.subject | melatonin | en |
Título | dc.title | Simultaneous determination of melatonin and pyridoxine in tablets by gas chromatography-mass spectrometry | en |
Document type | dc.type | Artículo de revista |
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