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Authordc.contributor.authorBollo Dragnic, Soledad 
Authordc.contributor.authorMuñoz, L.es_CL
Authordc.contributor.authorNúñez Vergara, Luis es_CL
Authordc.contributor.authorSquella Serrano, Juanes_CL
Admission datedc.date.accessioned2008-08-28T18:26:50Z
Available datedc.date.available2008-08-28T18:26:50Z
Publication datedc.date.issued2000-03
Cita de ítemdc.identifier.citationELECTROANALYSIS 12(5):376-382en
Identifierdc.identifier.issn1040-0397
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120481
Abstractdc.description.abstractTacrine, 9-amino-1,2,3,4-tetrahydroacridine, an antialzheimer's disease agent was electrochemically studied and a polarographic method For its quantitative determination in pharmaceuticals was developed. Tacrine was electrochemically reduced and oxidized in aqueous medium, but for analytical purposes the cathodic behavior was prefered. According to the linear relation between the peak current and the tacrine concentration a differential pulse polarographic method was developed. precision and accuracy of the dc rc loped method was checked by recovery studies. The proposed method was applied to the individual capsule assay (ICA) of the commercial capsules, showing that the uniformity content requirements were fulfilled. Alternatively a UV spectroscopic characterization was conducted from the pH dependence of the absorbance bands an apparent pK(a) of 10,44 was obtained. For comparative purposes a spectrophotomeric determination also was developed.en
Lenguagedc.language.isoenen
Publisherdc.publisherWILEY-V C H VERLAG GMBHen
Keywordsdc.subjectTacrineen
Títulodc.titleElectrochemical characterization of tacrine, an antialzheimer's disease drug, and its determination in pharmaceuticalsen
Document typedc.typeArtículo de revistaen


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