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Authordc.contributor.authorLarenas Gutiérrez, Gipsy 
Authordc.contributor.authorBollo Dragnic, Soledad es_CL
Authordc.contributor.authorRodríguez, M. es_CL
Authordc.contributor.authorLemus Gutiérrez, Igor es_CL
Authordc.contributor.authorNúñez Vergara, Luises_CL
Authordc.contributor.authorSquella Serrano, Juanes_CL
Authordc.contributor.authorÁlvarez Lueje, Alejandro es_CL
Admission datedc.date.accessioned2008-09-02T16:34:20Z
Available datedc.date.available2008-09-02T16:34:20Z
Publication datedc.date.issued2005-07
Cita de ítemdc.identifier.citationJOURNAL OF AOAC INTERNATIONAL 88(4):1135-1141en
Identifierdc.identifier.issn1060-3271
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120500
Abstractdc.description.abstractIn this work both the electrochemical behavior and the analysis of the hypnotic pyrazolopyrimidine derivative zaleplon were studied. Zaleplon in ethanol-0.1 M Britton Robinson buffer solution (30-70) showed 2 irreversible, well-defined cathodic responses in the pH range of 2-12 using differential pulse polarography (DPP), tast polarography, and cyclic voltammetry. From chronocoulometric studies, it was possible to conclude that one electron was transferred in each reduction peak or wave. For analytical purposes, the DPP technique working at pH 4.5 for peak I was selected, which exhibited adequate repeatability, reproducibility, and selectivity. The recovery was 99.97 +/- 1.52%, and the detection and quantitation limits were 5.13 x 10(-7) M and 1.11 X 10(-6)M, respectively. The DPP method was applied successfully to the individual assay of capsules in order to verify the content uniformity of zaleplon. Treatment of the sample is not required because the excipients do not interfere, the method is not time consuming, and it is less expensive than column liquid chromatography.en
Lenguagedc.language.isoenen
Publisherdc.publisherAOAC INTERNATIONALen
Keywordsdc.subjectVoltametríaen
Títulodc.titleVoltammetric behavior of zaleplon and its differential pulse polarographic determination in capsulesen
Document typedc.typeArtículo de revistaen


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