| Author | dc.contributor.author | Brain Isasi, S. | |
| Author | dc.contributor.author | Quezada Aburto, Cristián Salvador | es_CL |
| Author | dc.contributor.author | Pessoa Mahana, Hernán | es_CL |
| Author | dc.contributor.author | Morello Casté, Antonio | es_CL |
| Author | dc.contributor.author | Kogan Bocian, Marcelo | es_CL |
| Author | dc.contributor.author | Álvarez Lueje, Alejandro | es_CL |
| Admission date | dc.date.accessioned | 2008-09-29T17:44:43Z | |
| Available date | dc.date.available | 2008-09-29T17:44:43Z | |
| Publication date | dc.date.issued | 2008-08-15 | |
| Cita de ítem | dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY 16(16):7622-7630 | en |
| Identifier | dc.identifier.issn | 0968-0896 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120521 | |
| Abstract | dc.description.abstract | This work presents the development of analytical methodologies by UV spectrophotometry and HPLC to characterize five nitroarylbenzimidazole derivatives with activity against Trypanosoma cruzi: NB, BNB, PNB, PMNB and PCNB. Both methodologies exhibit adequate repeatabilities and reproducibilities (CV < 2%) and recoveries higher than 98%. The ionization constants (pK(a)), lipophilicity (log P) and effective permeability (Pe) are reported. The five compounds present an inhibitory effect on the T. cruzi growth (epimastigotes) at 1-100 mu M concentration range in an order rank of PMNB > PCNB > PNB > BNB > NB. Additionally, cyclic voltammetric data reveal that the nitroarylbenzimidazole derivatives might sustain their effects on growth and oxygen uptake on T. cruzi epimastigotes. | en |
| Lenguage | dc.language.iso | en | en |
| Publisher | dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en |
| Keywords | dc.subject | Benzimidazoles | en |
| Título | dc.title | Determination and characterization of new benzimidazoles with activity against Trypanosoma cruzi by UV spectroscopy and HPLC | en |
| Document type | dc.type | Artículo de revista | |
