| Author | dc.contributor.author | Tapia Villanueva, Cristián | |
| Author | dc.contributor.author | Corbalán, V. | es_CL |
| Author | dc.contributor.author | Costa, Edda | es_CL |
| Author | dc.contributor.author | Gai, María Nella | es_CL |
| Author | dc.contributor.author | Yazdani-Pedram Zobeiri, Mehrdad | es_CL |
| Admission date | dc.date.accessioned | 2008-11-13T10:18:08Z | |
| Available date | dc.date.available | 2008-11-13T10:18:08Z | |
| Publication date | dc.date.issued | 2005-09 | |
| Cita de ítem | dc.identifier.citation | AMER CHEMICAL SOC | en |
| Identifier | dc.identifier.issn | 1525-7797 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120560 | |
| Abstract | dc.description.abstract | The aim of this work was to establish the diltiazem hydrochloride release mechanism from the chitosan-alginate matrix tablet (MCB/AS) and chitosan-carrageenan matrix tablet (MCS/CSI). The weight loss for MCS/CSI is mainly due to the weight loss of the matrix while for MCB/AS it is mainly due to the diltiazem hydrochloride released from the tablet. Using the Peppa's model the release order for MCS/CSI was n = 1.07 +/- 0.13 and for MCB/AS was n = 0.76 +/- 0.02. Thus, MCS/CSI has a transport mechanism, and for MCB/AS the drug release mechanism is a combined process of diffusion and relaxation. MCB/AS has an elastic modulus (G' = 10(5) Pa) one order of magnitude higher than MCS/CSI (G' = 10(4) Pa). MCB/AS is able to uptake solvent without disrupting the microstructure due to its high elastic modulus. Instead MCS/ CSI showed a quick erosion process, which conducted to the tablet disintegration due to a fast solvent uptake process. | en |
| Lenguage | dc.language.iso | en | en |
| Publisher | dc.publisher | BIOMACROMOLECULES 6(5):2389-2395 | en |
| Keywords | dc.subject | Diltiazemhydrochloride | en |
| Título | dc.title | Study of the release mechanism of diltiazem hydrochloride from matrices based on chitosan-alginate and chitosan-carrageenan mixtures | en |
| Document type | dc.type | Artículo de revista | |
