Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae
Author | dc.contributor.author | Aguirre, María C. | |
Author | dc.contributor.author | Delporte Vergara, Carla | es_CL |
Author | dc.contributor.author | Backhouse Erazo, Nadine | es_CL |
Author | dc.contributor.author | Erazo, Silvia | es_CL |
Author | dc.contributor.author | Letelier Muñoz, María Eugenia | es_CL |
Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
Author | dc.contributor.author | Silva, Ximena | es_CL |
Author | dc.contributor.author | Alegría, Sergio | es_CL |
Author | dc.contributor.author | Negrete Córdova, Rosa | es_CL |
Admission date | dc.date.accessioned | 2009-07-01T18:21:24Z | |
Available date | dc.date.available | 2009-07-01T18:21:24Z | |
Publication date | dc.date.issued | 2006-08-15 | |
Cita de ítem | dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY 14(16):5673-5677 | en |
Identifier | dc.identifier.issn | 0968-0896 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120711 | |
Abstract | dc.description.abstract | Leaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material showed that some extracts have potent anti-inflammatory activities. Further fractionation led to the isolation and identification of betulinic acid, a mixture of ursolic and oleanolic acids, and the 2 alpha-hydroxy derivatives alphitolic, asiatic, and corosolic acids. The latter three were evaluated in vivo in the mouse ear assay for their topical anti-inflammatory activity, inducing inflammation with either arachidonic acid (AA) or 12-O-tetradecanoylphorbol-13 acetate (TPA). Only corosolic acid was active in the AA assay, with similar potency to nimesulide, but all three triterpene acids inhibited TPA-induced inflammation with potencies comparable to that of indomethacin. | en |
Lenguage | dc.language.iso | en | en |
Publisher | dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en |
Keywords | dc.subject | Ugni molinae | en |
Título | dc.title | Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae | en |
Document type | dc.type | Artículo de revista |
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