| Author | dc.contributor.author | Salazar González, Ricardo Andrés | |
| Author | dc.contributor.author | Navarrete Encina, Patricio | es_CL |
| Author | dc.contributor.author | Squella Serrano, Juan | es_CL |
| Author | dc.contributor.author | Camargo Grandón, Rodrigo | es_CL |
| Author | dc.contributor.author | Núñez Vergara, Luis | es_CL |
| Admission date | dc.date.accessioned | 2009-08-13T16:00:54Z | |
| Available date | dc.date.available | 2009-08-13T16:00:54Z | |
| Publication date | dc.date.issued | 2009-06 | |
| Cita de ítem | dc.identifier.citation | JOURNAL OF PHYSICAL ORGANIC CHEMISTRY 22(6): 569-577 | en |
| Identifier | dc.identifier.issn | 0894-3230 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120758 | |
| Abstract | dc.description.abstract | Reactivity of two new C4-indolyl substituted 1,4-dihydropyridines (1,4-DHPs) toward superoxide anion (O-2) in dimethylsulfoxide (DMSO) is reported. Reactivity was followed by electrochemical and spectroscopic techniques. Gas chromatography-mass spectrometry (GC-MS) was used to identify the final products of the reaction. C4 indolyl-substituted- 1,4-DHPs reacted toward O-2 at Significant rates, according to the calculated kinetic rate constants. Results are compared with 4-phenyl-DHP and the commercial 1,4-DHPs, nimodipine, nisoldipine, and amlodipine. Indolyl-substituted 1,4-DHPs were more reactive than the commercial derivatives. The direct participation of proton of the 1-position of the secondary amine in the quenching Of O-2 was demonstrated. | en |
| Lenguage | dc.language.iso | en | en |
| Publisher | dc.publisher | JOHN WILEY & SONS LTD | en |
| Keywords | dc.subject | C4-indolyl substituted 1,4-dihydropyridines | en |
| Título | dc.title | Reactivity of C4-indolyl substituted 1,4-dihydropyridines toward superoxide anion (O-2((center dot)under-bar)) in dimethylsulfoxide | en |
| Document type | dc.type | Artículo de revista | |
