Author | dc.contributor.author | Porcal, Williams | |
Author | dc.contributor.author | Hernández, Paola | es_CL |
Author | dc.contributor.author | González, Mercedes | es_CL |
Author | dc.contributor.author | Ferreira, Ana | es_CL |
Author | dc.contributor.author | Olea Azar, Claudio | es_CL |
Author | dc.contributor.author | Cerecetto, Hugo | es_CL |
Author | dc.contributor.author | Castro, Ana | es_CL |
Admission date | dc.date.accessioned | 2010-01-13T17:27:24Z | |
Available date | dc.date.available | 2010-01-13T17:27:24Z | |
Publication date | dc.date.issued | 2008-09 | |
Cita de ítem | dc.identifier.citation | Journal Medicinal Chemistry, 51 (19), pp 6150–6159, 2008 | en_US |
Identifier | dc.identifier.issn | 1520-4804 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120850 | |
Abstract | dc.description.abstract | New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents
on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the
oxidative damage and the death induced by exposure to hydrogen peroxide. These heteroarylnitrones showed
excellent peroxyl free radical absorbance capacities, analyzed by oxygen radical absorbance capacity (ORAC)
assay with fluorescein as the fluorescent probe, ranging from 1.5- to 16.5-fold the value of the reference
nitrone, R-phenyl-N-tert-butylnitrone (PBN). The electron spin resonance spectroscopy (ESR) demonstrated
the ability of these derivatives to directly trap and stabilize oxygen, carbon, and sulfur-centered free radicals.
These results demonstrated the potential use of these heteroarylnitrones as neuroprotective agents in preventing
the death of cells exposed to enhanced oxidative stress and damage. | en_US |
Patrocinador | dc.description.sponsorship | The authors thank Collaborative Project
UdelaR (Uruguay), CSIC (Spain) (Grant 2006UY0009), and
Neuropharma S.A (Madrid, Spain). W.P. thanks Collaborative
Project (Grant 2006UY0009) and CSIC (UdelaR) for fellowships. | en_US |
Lenguage | dc.language.iso | en | en_US |
Publisher | dc.publisher | American Chemical Society | en_US |
Título | dc.title | Heteroarylnitrones as Drugs for Neurodegenerative Diseases: Synthesis, Neuroprotective Properties, and Free Radical Scavenger Properties | en_US |
Document type | dc.type | Artículo de revista | |