| Author | dc.contributor.author | Aránguiz Urroz, Pablo Daniel | |
| Author | dc.contributor.author | Soto Muñoz, Dagoberto | es_CL |
| Author | dc.contributor.author | Contreras Ferrat, Ariel Eduardo | es_CL |
| Author | dc.contributor.author | Troncoso Cotal, Rodrigo | es_CL |
| Author | dc.contributor.author | Chiong Lay, Mario | es_CL |
| Author | dc.contributor.author | Montenegro Obregón, José Joaquín | es_CL |
| Author | dc.contributor.author | Venegas Pino, Daniel Esteban | es_CL |
| Author | dc.contributor.author | Smolic Smolic, Christian | es_CL |
| Author | dc.contributor.author | Ayala Jeria, Pedro Segundo | es_CL |
| Author | dc.contributor.author | Thomas, W. G. | es_CL |
| Author | dc.contributor.author | Lavandero González, Sergio | es_CL |
| Author | dc.contributor.author | Díaz Araya, Guillermo | es_CL |
| Admission date | dc.date.accessioned | 2010-04-07T21:24:15Z | |
| Available date | dc.date.available | 2010-04-07T21:24:15Z | |
| Publication date | dc.date.issued | 2009-05 | |
| Cita de ítem | dc.identifier.citation | AMERICAN JOURNAL OF HYPERTENSION 22(5): 569-576 | en_US |
| Identifier | dc.identifier.issn | 0895-7061 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120932 | |
| Abstract | dc.description.abstract | The Angiotensin II (Ang II) type 1 (AT(1)R) and type 2 (AT(2)R) receptors are increased in the heart following myocardial infarction and dilated cardiomyopathy, yet their contribution at a cellular level to compensation and/or failure remains controversial.
METHODS
We ectopically expressed AT(1)R and AT(2)R in cultured adult rat cardiomyocytes and cardiac fibroblasts to investigate Ang II-mediated cardiomyocyte hypertrophy and cardiac cell viability.
RESULTS
In adult rat cardiomyocytes, Ang II did not induce hypertrophy via the AT(1)R, and no effect of Ang II on cell viability was observed following AT(1)R or AT(2)R expression. In adult rat cardiac fibroblasts, Ang II stimulated cell death by apoptosis via the AT(1)R (but not the AT(2)R), which required the presence of extracellular calcium, and induced a rapid dissipation of mitochondrial membrane potential, which was significant from 8 h.
CONCLUSIONS
We conclude that Ang II/AT(1)R triggers apoptosis in adult rat cardiac fibroblasts, which is dependent on Ca2+ influx. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | NATURE PUBLISHING GROUP | en_US |
| Keywords | dc.subject | VENTRICULAR MYOCYTES | en_US |
| Título | dc.title | Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin II | en_US |
| Document type | dc.type | Artículo de revista | |
