| Author | dc.contributor.author | Olea Azar, Claudio | |
| Author | dc.contributor.author | Rigol Olsen, Carolina | es_CL |
| Author | dc.contributor.author | Opazo, L. | es_CL |
| Author | dc.contributor.author | Morello Casté, Antonio | es_CL |
| Author | dc.contributor.author | Maya Arango, Juan | es_CL |
| Author | dc.contributor.author | Repetto Scaramelli, Yolanda | es_CL |
| Author | dc.contributor.author | Aguirre, G. | es_CL |
| Author | dc.contributor.author | Cerecetto, Hugo | es_CL |
| Author | dc.contributor.author | Di Maio, R. | es_CL |
| Author | dc.contributor.author | González, M. | es_CL |
| Author | dc.contributor.author | Porcal, Williams | es_CL |
| Admission date | dc.date.accessioned | 2010-06-08T15:17:59Z | |
| Available date | dc.date.available | 2010-06-08T15:17:59Z | |
| Publication date | dc.date.issued | 2003-12 | |
| Cita de ítem | dc.identifier.citation | JOURNAL OF THE CHILEAN CHEMICAL SOCIETY 48 (4): 77-79 | en_US |
| Identifier | dc.identifier.issn | 0717-9324 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120975 | |
| Abstract | dc.description.abstract | The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation of free radicals in the trypanosome microsomal system. The Nitro 2 (4-(n-butyl)-1-(5-nitrofurfurylidene)semicarbazide) analogue of Nifurtimox showed better antiparasitic activity than N-oxide 1 (4-(n-butyl)-1-[(7-bromo-N1-oxidebenzo[1,2-c]1,2,5-oxadiazole-5-yl)methylidene]semicarbazide). Only Nitro 2 could produce oxygen redox cycling in T. cruzi epimastigotes. The ESR signal intensities were consistent with the trapping of hydroxyl radical. These results are in agreement with the biological observation that Nitro 2 showed antichagasic activity by an oxidative stress mechanism. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | SOCIEDAD CHILENA DE QUIMICA | en_US |
| Keywords | dc.subject | Nitrofuran derivatives | en_US |
| Título | dc.title | ESR and spin trapping studies of two new potential antitrypanosomal drugs | en_US |
| Document type | dc.type | Artículo de revista | |
