| Author | dc.contributor.author | Rojas Rivera, Andrés | |
| Author | dc.contributor.author | Díaz Elizondo, Jessica | es_CL |
| Author | dc.contributor.author | Parra Ortíz, María Valentina | es_CL |
| Author | dc.contributor.author | Salas, Daniela | es_CL |
| Author | dc.contributor.author | Contreras Ferrat, Ariel Eduardo | es_CL |
| Author | dc.contributor.author | Toro, Barbra | es_CL |
| Author | dc.contributor.author | Chiong Lay, Mario | es_CL |
| Author | dc.contributor.author | Olea Azar, Claudio | es_CL |
| Author | dc.contributor.author | Lavandero González, Sergio | es_CL |
| Admission date | dc.date.accessioned | 2010-06-09T20:32:36Z | |
| Available date | dc.date.available | 2010-06-09T20:32:36Z | |
| Publication date | dc.date.issued | 2009-11-03 | |
| Cita de ítem | dc.identifier.citation | FEBS LETTERS 583 (21): 3485-3492 | en_US |
| Identifier | dc.identifier.issn | 0014-5793 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120984 | |
| Abstract | dc.description.abstract | We investigated the role of Ca2+ in generating reactive oxygen species (ROS) induced by hyposmotic stress (Hypo) and its relationship to regulatory volume decrease (RVD) in cardiomyocytes. Hypo-induced increases in cytoplasmic and mitochondrial Ca2+. Nifedipine (Nife) inhibited both Hypo-induced Ca2+ and ROS increases. Overexpression of catalase (CAT) induced RVD and a decrease in Hypo-induced blebs. Nife prevented CAT-dependent RVD activation. These results show a dual role of Hypo-induced Ca2+ influx in the control of cardiomyocyte viability. Hypo-induced an intracellular Ca2+ increase which activated RVD and inhibited necrotic blebbing thus favoring cell survival, while simultaneously increasing ROS generation, which in turn inhibited RVD and induced necrosis. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | ELSEVIER SCIENCE BV | en_US |
| Keywords | dc.subject | Ca2+ | en_US |
| Título | dc.title | Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species | en_US |
| Document type | dc.type | Artículo de revista | |
