| Author | dc.contributor.author | Jalil Milad, Jorge | |
| Author | dc.contributor.author | Ebensperger González, Roberto | es_CL |
| Author | dc.contributor.author | Meléndez Vergara, Jaime | es_CL |
| Author | dc.contributor.author | Acevedo, E. | es_CL |
| Author | dc.contributor.author | Sapag Hagar, Mario | es_CL |
| Author | dc.contributor.author | González Jara, Fabián Rodrigo | es_CL |
| Author | dc.contributor.author | Gálvez, Anita | es_CL |
| Author | dc.contributor.author | Pérez Montes, Viviana | es_CL |
| Author | dc.contributor.author | Lavandero González, Sergio | es_CL |
| Admission date | dc.date.accessioned | 2011-04-12T14:20:15Z | |
| Available date | dc.date.available | 2011-04-12T14:20:15Z | |
| Publication date | dc.date.issued | 1999-03-26 | |
| Cita de ítem | dc.identifier.citation | LIFE SCIENCES 64 (18): 1603-1612 | en_US |
| Identifier | dc.identifier.issn | 0024-3205 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/121171 | |
| Abstract | dc.description.abstract | There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and a-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drugs in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, a-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-I contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
| Keywords | dc.subject | GROWTH-FACTOR-I | en_US |
| Título | dc.title | Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat | en_US |
| Document type | dc.type | Artículo de revista | |
