Polarographic determination of nitrofurazone and furazolidone in pharmaceutical formulations and urine
Author | dc.contributor.author | Morales, A. | |
Author | dc.contributor.author | Richter Duk, Pablo | es_CL |
Author | dc.contributor.author | Toral Ponce, María | es_CL |
Admission date | dc.date.accessioned | 2011-06-03T14:16:59Z | |
Available date | dc.date.available | 2011-06-03T14:16:59Z | |
Publication date | dc.date.issued | 1987 | |
Cita de ítem | dc.identifier.citation | Analyst 112: 971-973 | es_CL |
Identifier | dc.identifier.issn | 0003-2654 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/121246 | |
Abstract | dc.description.abstract | In pyridine - formic acid buffer and tetramethylammonium chloride solution over the pH range 0-8.5, nitrofurazone, furazolidone and other nitrofuran derivatives are reduced in a six-electron process, giving rise to a well defined polarographic reduction wave at a dropping mercury electrode. The current is difussion controlled and proportional to the concentration from about 5.88 x 10-3M to the limit of detection of 1.24 x10-6M. The proposed method permits these drugs to be determined, without any prior separation or extraction, in pharmaceutical formulations and in urine at levels at which the unchanged drugs are excreted. Other drugs commonly used as therapeutic agents, such as nitro derivatives of 1,4-benzodiazepines,chloramphenicol, metronidazole and tinidazole, are reduced in a single four-electron process at more negative potentials, which makes simultaneous determinations possible. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | Royal Society of Chemistry | es_CL |
Keywords | dc.subject | Nitrofurazone | es_CL |
Título | dc.title | Polarographic determination of nitrofurazone and furazolidone in pharmaceutical formulations and urine | es_CL |
Document type | dc.type | Artículo de revista |
Files in this item
This item appears in the following Collection(s)
-
Artículos de revistas
Artículos de revistas