| Abstract | dc.description.abstract | An electrochemical study of the (+/-)-1-(2,5-DIMETHOXY-4-NITROPHENYL)-2-AMINOPROPANE, which differs from similar compounds in that a hydrophilic nitro group replaces hydrophobic substituents on the 4-position of the benzene ring, was carried out using a solvent - buffer system containing pyridine - formic acid and tetramethylammonium chloride solution. Polarographically and voltammetrically the drug behaves as other structurally related aromatic nitro derivatives, the nitro group being reduced to the hydroxylamine in a single, well defined irreversible, diffusion-controlled and pH-dependent wave. The E1/2 versus pH and ilim versus pH relationhips were examined and cyclic voltammograms were recorded at different pH values and at different scan rates in order to elucidate the reduction mechanism and to identify relatively unstable intermediate species. The results of this study suggest that a significant relationship can be established between the electrochemical behaviour of any compound and its molecular - electronic structure, and between molecular structure and pharmaceutical or biological activity, as confirmed recently by quantitative structure - activity relationship studies. | es_CL |
