Author | dc.contributor.author | Insuasty, B. | |
Author | dc.contributor.author | Torres, H. | es_CL |
Author | dc.contributor.author | Quiroga, J. | es_CL |
Author | dc.contributor.author | Abonia, R. | es_CL |
Author | dc.contributor.author | Rodríguez, R. | es_CL |
Author | dc.contributor.author | Nogueras, M. | es_CL |
Author | dc.contributor.author | López Sánchez, A. | es_CL |
Author | dc.contributor.author | Saitz Barría, Claudio | es_CL |
Author | dc.contributor.author | Alvarez, S. L. | es_CL |
Author | dc.contributor.author | Zacchino, Susana | es_CL |
Admission date | dc.date.accessioned | 2011-06-30T13:02:04Z | |
Available date | dc.date.available | 2011-06-30T13:02:04Z | |
Publication date | dc.date.issued | 2006 | |
Cita de ítem | dc.identifier.citation | Boletín de la Sociedad Chilena de Química 51 (2): 927-932 | es_CL |
Identifier | dc.identifier.issn | 0717-9324 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/121357 | |
General note | dc.description | Artículo de publicación ISI | es_CL |
Abstract | dc.description.abstract | The synthesis of a series of new benzimidazo [1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is decsribe. The structure elucidation of the products is based on detailed NMR analysis of experiments such as 'H-COSY,NOESY,DEPT,HSQC and HMBC. These compounds showed antifungal properties only against dermatophytes. Among them, those with electron-donor substituents on the 6-phenyl ring inhibitied mainly T. rubrum and E. floccossum with MICs between 25-250 ug/mL and M. canis, M. gypseum and T. mentagrophytes with MICs between 50-250 ug//mL. Structures with electron-witbdrawing substituents on the phenyl ring did not show any activities up to 250 ug//mL. Methyl substituents on the benzimidazole ring seem negatively affect the antifungal behaviour of this series. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | Sociedad Chilena de Química | es_CL |
Keywords | dc.subject | Benzimidazo [1,2-c]quinazolines | es_CL |
Título | dc.title | Synthesis, characterization and in vitro antifungal elevation of novel benzimidazo [1,2-c]quinazolines | es_CL |
Document type | dc.type | Artículo de revista | |