Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice
Author | dc.contributor.author | Arrau, Sylvia | |
Author | dc.contributor.author | Delporte Vergara, Carla | es_CL |
Author | dc.contributor.author | Cartagena, Carlos | es_CL |
Author | dc.contributor.author | Rodríguez Díaz, Maité | es_CL |
Author | dc.contributor.author | González, Patricia | es_CL |
Author | dc.contributor.author | Silva, Ximena | es_CL |
Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
Author | dc.contributor.author | Miranda Guzmán, Hugo | es_CL |
Admission date | dc.date.accessioned | 2011-10-17T15:29:17Z | |
Available date | dc.date.available | 2011-10-17T15:29:17Z | |
Publication date | dc.date.issued | 2011-01-07 | |
Cita de ítem | dc.identifier.citation | JOURNAL OF ETHNOPHARMACOLOGY Volume: 133 Issue: 1 Pages: 164-167 Published: JAN 7 2011 | es_CL |
Identifier | dc.identifier.issn | 0378-8741 | |
Identifier | dc.identifier.other | DOI: 10.1016/j.jep.2010.09.016 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/121610 | |
Abstract | dc.description.abstract | Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3 ,16 -dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3 ,16 -dihydroxy-23- oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate. Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively. Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en-28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium. Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models. | es_CL |
Patrocinador | dc.description.sponsorship | This work was partially supported by Fondecyt Grant No. 1080174 and ICM Grant No. P05- 001-F. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | Elsevier | es_CL |
Keywords | dc.subject | Analgesic activity | es_CL |
Título | dc.title | Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice | es_CL |
Document type | dc.type | Artículo de revista |
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