Release of Methylene Blue from dioctadecyldimethylammonium chloride vesicles
Author
dc.contributor.author
Zanocco Loyola, Antonio
Author
dc.contributor.author
Günther Sapunar, Germán
es_CL
Author
dc.contributor.author
Lemp Miranda, Else
es_CL
Author
dc.contributor.author
Lissi Gervaso, Eduardo A.
es_CL
Admission date
dc.date.accessioned
2013-12-19T19:59:12Z
Available date
dc.date.available
2013-12-19T19:59:12Z
Publication date
dc.date.issued
1998
Cita de ítem
dc.identifier.citation
J. Chem. Soc., Perkin Trans. 2, 1998
en_US
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/121682
General note
dc.description
Artículo de publicación ISI
Abstract
dc.description.abstract
The cationic dye Methylene Blue included in the internal aqueous microphase of dioctadecyldimethylammonium
chloride (DODAC) vesicle shows the typical monomer–dimer equilibrium observed in
homogenous aqueous solutions. Using a simple spectrophotometric method, values of 54 000 ± 1300 M21
cm21 and 3860 ± 130 M21 have been obtained for the extinction coefficient of Methylene Blue monomer
at 680 nm (åM
680) and the equilibrium constant (K), respectively, in homogeneous aqueous solution at 20 8C.
At this wavelength dimer absorbance is negligible. Leakage of Methylene Blue from the inner aqueous
pseudophase can be described in terms of Fick’s law. The dependence of the release rate on monomer
concentration, the value of the permeability constant (1.09 × 1029 cm s21 at 20.3 8C) and the dependence
of the release rate on NaCl addition suggest that Methylene Blue diffuses across the lipidic bilayer of the
vesicle as a monomer.