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Author dc.contributor.author Pessoa Mahana, Hernán
Author dc.contributor.author González Lira, Christian es_CL
Author dc.contributor.author Fierro, Angélica es_CL
Author dc.contributor.author Zapata Torres, Gerald Amilcar es_CL
Author dc.contributor.author Pessoa Mahana, Carlos David es_CL
Author dc.contributor.author Ortiz Severin, Javiera es_CL
Author dc.contributor.author Iturriaga-Vásquez, Patricio es_CL
Author dc.contributor.author Reyes Parada, Miguel es_CL
Author dc.contributor.author Silva Matus, Paul es_CL
Author dc.contributor.author Saitz Barría, Claudio es_CL
Author dc.contributor.author Araya Maturana, Ramiro es_CL
Admission date dc.date.accessioned 2014-01-13T12:56:49Z
Available date dc.date.available 2014-01-13T12:56:49Z
Publication date dc.date.issued 2013
Cita de ítem dc.identifier.citation Bioorganic & Medicinal Chemistry 21 (2013) 7604–7611 en_US
Identifier dc.identifier.other DOI: 10.1016/j.bmc.2013.10.036
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/121748
General note dc.description Artículo de publicación ISI en_US
Abstract dc.description.abstract A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a–d and 5a–
f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin
transporter (SERT) and the 5-HT1A receptor. Compounds 5b and 5f showed nanomolar affinities for both
targets. The experimental data were rationalized according to results obtained from docking experiments.
These findings are in agreement with our proposal that bis-indole derivatives can bind both targets,
and might serve as leads in the quest of ligands endowed with a dual mechanism of action. en_US
Lenguage dc.language.iso en en_US
Publisher dc.publisher Elsevier en_US
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile *
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ *
Keywords dc.subject Piperazinylpropylindole derivatives en_US
Título dc.title Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor en_US
Document type dc.type Artículo de revista
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