Alpha-tocopherol microspheres with cross-linked and acetylated inulin and their release profile in a hydrophilic model
Author
dc.contributor.author
García, Paula
Author
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Vega, Juan
es_CL
Author
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Jimenez, Paula
es_CL
Author
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Santos, José
es_CL
Author
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Paz Soledad, Robert Canales
es_CL
Admission date
dc.date.accessioned
2014-01-27T19:52:34Z
Available date
dc.date.available
2014-01-27T19:52:34Z
Publication date
dc.date.issued
2013-07
Cita de ítem
dc.identifier.citation
Eur. J. Lipid Sci. Technol. 2013, 115, 811–819
en_US
Identifier
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doi: 10.1002/ejlt.201200109
Identifier
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https://repositorio.uchile.cl/handle/2250/121773
General note
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Artículo de publicación ISI.
en_US
Abstract
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Alpha-tocopherol (AT) was encapsulated with native (NIn), acetylated (AIn) or cross-linked (CIn) inulin (two degrees each) by spray-drying. A face central composite experimental design for each system (AT-NIn, AT-AIn(1), AT-AIn(2), AT-CIn1, and AT-CIn2) was evaluated to determine the influence of inlet air temperature and AT/coating material ratio on the AT encapsulation percentage (EP). The AT microspheres obtained under optimal conditions were characterized determining the AT EP, morphology and their release profile in a hydrophilic system. The AT encapsulating percentage reached values above 86% in all the systems studied. The acetylation and cross-linking of inulin improved slight but significantly the AT encapsulating percentage respect to native inulin. The release profiles showed biphasic behavior, being the first and second zone attributed to uncovered and encapsulated AT, respectively. The AT release was <15% (0-540min) from all AT-inulin microparticles, corresponding mainly to superficial AT release, following Higuchi model consistent with a diffusional mechanism. AT release rate constant from AT-NIn microspheres was significantly lower than those of AT-AIn and AT-CIn. The AT release pattern suggest that the microparticles could be applied in the design of functional foods, preserving the nutritional role of AT.
en_US
Patrocinador
dc.description.sponsorship
Grant No. 1090209 from The National
Fund for Scientific and Technological Development (Fondecyt,
Chile).