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Authordc.contributor.authorTroncoso, Rodrigo 
Authordc.contributor.authorDíaz Elizondo, Jessica es_CL
Authordc.contributor.authorEspinoza, Sandra P. es_CL
Authordc.contributor.authorNavarro Márquez, Mario F. es_CL
Authordc.contributor.authorOyarzún, Alejandra P. es_CL
Authordc.contributor.authorRiquelme, Jaime A. es_CL
Authordc.contributor.authorGarcía Carvajal, Ivonne es_CL
Authordc.contributor.authorDíaz Araya, Guillermo es_CL
Authordc.contributor.authorGarcía Nannig, Lorena es_CL
Authordc.contributor.authorHill, Joseph A. es_CL
Authordc.contributor.authorLavandero González, Sergioes_CL
Cita de ítemdc.identifier.citationIUBMB Life, 65(7):593–601, 2013en_US
Identifierdc.identifier.otherDOI: 10.1002/iub.1172
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractInsulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal-regulated kinase (ERK), and phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3)/ Ca21. The Akt/mTOR and Ras/Raf/ERK signaling arms govern survival in the settings of cardiac stress and hypertrophic growth. By contrast, PLC/InsP3/Ca21 functions to regulate metabolic adaptability and gene transcription. Autophagy is a catabolic process involved in protein degradation, organelle turnover, and nonselective breakdown of cytoplasmic components during nutrient starvation or stress. In the heart, autophagy is observed in a variety of human pathologies, where it can be either adaptive or maladaptive, depending on the context. We proposed the hypothesis that IGF-1 protects the heart by rescuing the mitochondrial metabolism and the energetics state, reducing cell death and controls the potentially exacerbate autophagic response to nutritional stress. In light of the importance of IGF-1 and autophagy in the heart, we review here IGF-1 signaling and autophagy regulation in the context of cardiomyocyte nutritional stress.en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectsignal transductionen_US
Títulodc.titleRegulation of Cardiac Autophagy by Insulin-like Growth Factor 1en_US
Document typedc.typeArtículo de revista

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile