Sleep for Preserving and Transforming Episodic Memory
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2013Metadata
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Inostroza Herrera, Marion Alejandra
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Sleep for Preserving and Transforming Episodic Memory
Abstract
Sleep is known to support memory consolidation. Here we review evidence
for an active system consolidation occurring during sleep. At
the beginning of this process is sleep’s ability to preserve episodic experiences
preferentially encoded in hippocampal networks. Repeated
neuronal reactivation of these representations during slow-wave sleep
transforms episodic representations into long-term memories, redistributes
them toward extrahippocampal networks, and qualitatively
changes them to decontextualized schema-like representations. Electroencephalographic
(EEG) oscillations regulate the underlying communication:
Hippocampal sharp-wave ripples coalescing with thalamic
spindles mediate the bottom-up transfer of reactivated memory information
to extrahippocampal regions. Neocortical slow oscillations exert
a supraordinate top-down control to synchronize hippocampal reactivations
of specific memories to their excitable up-phase, thus allowing
plastic changes in extrahippocampal regions. We propose that reactivations
during sleep are a general mechanism underlying the abstraction of
temporally stable invariants from a flow of input that is solely structured
in time, thus representing a basic mechanism of memory formation.
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Artículo de publicación ISI
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URI: https://repositorio.uchile.cl/handle/2250/121984
DOI: doi 10.1146/annurev-neuro-062012-170429
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Annu. Rev. Neurosci. 2013. 36:79–102
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