Maternal sympathetic stress impairs follicular development and puberty of the offspring
Author
dc.contributor.author
Barra, Rafael
Author
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Cruz Neculpán, Gonzalo Andrés
es_CL
Author
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Mayerhofer, Artur
es_CL
Author
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Paredes Vargas, Alfonso
es_CL
Author
dc.contributor.author
Lara Peñaloza, Hernán
es_CL
Admission date
dc.date.accessioned
2015-01-08T20:21:16Z
Available date
dc.date.available
2015-01-08T20:21:16Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
Reproduction (2014) 148 137–145
en_US
Identifier
dc.identifier.issn
1470–1626
Identifier
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DOI: 10.1530/REP-14-0150
Identifier
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https://repositorio.uchile.cl/handle/2250/121985
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
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Chronic cold stress applied to adult rats activates ovarian sympathetic innervation and develops polycystic ovary (PCO) phenotype.
The PCO syndrome in humans originates during early development and is expressed before or during puberty, which suggests that the
condition derived from in utero exposure to neural- or metabolic-derived insults.We studied the effects of maternal sympathetic stress on
the ovarian follicular development and on the onset of puberty of female offspring. Timed pregnant rats were exposed to chronic cold
stress (4 8C, 3 h/daily from 1000 to 1300 h) during the entire pregnancy. Neonatal rats exposed to sympathetic stress during gestation had
a lower number of primary, primordial, and secondary follicles in the ovary and a lower recruitment of primary and secondary follicles
derived from the primordial follicular pool. The expression of the FSH receptor and response of the neonatal ovary to FSH were reduced.
A decrease in nerve growth factor (NGF) mRNA was found without change in the low-affinity NGF receptor. The FSH-induced
development of secondary follicles was decreased. At puberty, estradiol plasma levels decreased without changes in LH plasma levels.
Puberty onset (as shown by the vaginal opening) was delayed. Ovarian norepinephrine (NE) was reduced; there was no change in its
metabolite, 3-methoxy-4-hydroxyphenylglycol, in stressed rats and no change in NE turnover. The changes in ovarian NE in prepubertal
rats stressed during gestation could represent a lower development of sympathetic nerves as a compensatory response to the chronically
increased NE levels during gestation and hence participate in delaying reproductive performance in the rat.
en_US
Patrocinador
dc.description.sponsorship
This work was supported, in part, by Fondecyt grant number
1130049 (to H E Lara) and Conicyt grant for doctoral thesis
number 2411061 (to R Barra) and from Deutsche Forschungsgemeinschaft
DFG 1080/19-1 and 1080/17-1 (to AMayerhofer)
and Conicyt-PIA-DFG10 binational program.