| Author | dc.contributor.author | Dutzan Muñoz, Nicolás | es_CL |
| Author | dc.contributor.author | Rivas, Catalina | es_CL |
| Author | dc.contributor.author | García Sesnich, Jocelyn | es_CL |
| Author | dc.contributor.author | Henríquez, Leslie | es_CL |
| Author | dc.contributor.author | Rivera Escobar, Oriana | es_CL |
| Author | dc.contributor.author | Dezerega Piwonka, Andrea | es_CL |
| Author | dc.contributor.author | Hernández Ríos, Emma | es_CL |
| Author | dc.contributor.author | Silva Steffens, Nora | es_CL |
| Author | dc.contributor.author | Aguillón Gutiérrez, Juan Carlos | es_CL |
| Author | dc.contributor.author | Puente Piccardo, Javier | es_CL |
| Author | dc.contributor.author | Vernal Astudillo, Rolando | |
| Author | dc.contributor.author | Gamonal Aravena, Jorge Antonio | es_CL |
| Admission date | dc.date.accessioned | 2012-01-10T14:22:28Z | |
| Available date | dc.date.available | 2012-01-10T14:22:28Z | |
| Publication date | dc.date.issued | 2011-10 | |
| Cita de ítem | dc.identifier.citation | J Periodontol. 2011 Oct;82(10):1483-9. | es_CL |
| Identifier | dc.identifier.issn | 0022-3492 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/123437 | |
| Abstract | dc.description.abstract | BACKGROUND: A growing body of evidence suggested that interleukin (IL)-21 enhances the effector phase during T-cell responses. The aim of our study is to determine the levels of IL-21 in periodontal sites from patients with chronic periodontitis and controls.
METHODS: The population studied consisted of 34 patients (15 with chronic periodontitis and 19 healthy patients). Twenty samples (10 gingival crevicular fluid [GCF] and 10 gingival biopsies) were collected from each group before the patients with periodontitis received periodontal treatment. Total protein concentrations were measured in all samples; the presence of IL-21 was confirmed by immunohistochemistry and Western blot, and IL-21 levels were quantified through an enzyme-linked immunosorbent assay. Statistical analyses were performed using statistical software. Data were expressed as patient means ± SDs or medians (interquartile ranges) by using the χ(2), Student t, and Mann-Whitney U tests.
RESULTS: GCF IL-21 was mainly detected in patients with chronic periodontitis (P <0.05). Levels of IL-21 in gingival tissues were significantly higher in patients with chronic periodontitis compared to healthy individuals (P <0.05). The Western blot and immunohistochemical staining confirmed the presence of IL-21 in periodontal tissues and GCF.
CONCLUSION: IL-21 was highly expressed in patients with chronic periodontitis, especially in gingival biopsies; therefore, IL-21 might play a role in the T-cell response. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | American Academy of Periodontology | es_CL |
| Keywords | dc.subject | Cytokines | es_CL |
| Título | dc.title | Levels of interleukin-21 in patients with untreated chronic periodontitis | es_CL |
| Document type | dc.type | Artículo de revista | |
