Tumor necrosis factor-astimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
| Author | dc.contributor.author | Smith, P. C. | |
| Author | dc.contributor.author | Guerrero, J. | es_CL |
| Author | dc.contributor.author | Tobar, N. | es_CL |
| Author | dc.contributor.author | Cáceres, M. | es_CL |
| Author | dc.contributor.author | González Burgos, María Julieta | es_CL |
| Author | dc.contributor.author | Martínez Winkler, Jorge | es_CL |
| Admission date | dc.date.accessioned | 2014-01-10T14:17:27Z | |
| Available date | dc.date.available | 2014-01-10T14:17:27Z | |
| Publication date | dc.date.issued | 2007-12-11 | |
| Cita de ítem | dc.identifier.citation | J Periodont Res 2009; 44: 73–80 | en_US |
| Identifier | dc.identifier.other | doi:10.1111/j.1600-0765.2007.01081.x | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/123508 | |
| Abstract | dc.description.abstract | Membrane type 1-matrix metalloproteinase (MT1- MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the production of proteolytic enzymes. Mice deficient in epidermal growth factor receptor (EGFR) show a reduced expression of MT1-MMP, suggesting that this receptor may play an important role in MT1-MMP production. The present study evaluated the role of the inflammatory cytokine tumor necrosis factor-a (TNF-a) and EGFR in the production of MT1-MMP in gingival fibroblasts. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | Blackwell Munksgaard | en_US |
| Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | * |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| Keywords | dc.subject | tumor necrosis factor-a; epidermal growth factor receptor; membrane type 1-matrix metalloproteinase; fibroblast | en_US |
| Título | dc.title | Tumor necrosis factor-astimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts | en_US |
| Document type | dc.type | Artículo de revista |
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