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Rosiglitazone maleate 0.25-hydrate: a pseudopolymorphic form

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2008-03
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Cuffini, Silvia L.
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Rosiglitazone maleate 0.25-hydrate: a pseudopolymorphic form
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Author
  • Cuffini, Silvia L.;
  • Faudone, Sonia;
  • Ferro, Maribel;
  • Garland, María Teresa;
  • Baggio, Ricardo;
Abstract
The present 0.25-hydrated form of rosiglitazone maleate [ systematic name: ( +/-)-2-({2-[2,4-dioxo-1,3-thiazolidin-5-ylmethyl) phenoxy] ethyl} methylamino) pyridinium maleate 0.25 hydrate], C18H20N3O3S+center dot C4H3O4- .0.25H(2)O, is a racemate with two independent moieties in the unit cell. Although the cation geometry does not differ substantially from that in the previously reported hydrochloride, the packing is quite different, the main feature being the formation of hydrogen-bonded tetramers, linked head-to-tail into weakly interacting chains.
Identifier
URI: https://repositorio.uchile.cl/handle/2250/125139
DOI: 10.1107/S0108270107054443
ISSN: 0108-2701
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ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS Volume: 64 Pages: O119-O122 Part: Part 3 Published: MAR 2008
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