| Author | dc.contributor.author | Hart, Andrew | |
| Author | dc.contributor.author | Martínez Aguilera, Servet | es_CL |
| Author | dc.contributor.author | Olmos, Felipe | es_CL |
| Admission date | dc.date.accessioned | 2012-06-12T14:47:38Z | |
| Available date | dc.date.available | 2012-06-12T14:47:38Z | |
| Publication date | dc.date.issued | 2012 | |
| Cita de ítem | dc.identifier.citation | J Stat Phys (2012) 146:408–422 | es_CL |
| Identifier | dc.identifier.other | DOI 10.1007/s10955-011-0377-6 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/125634 | |
| Abstract | dc.description.abstract | Chargaff’s second parity rule (CSPR) asserts that the frequencies of short polynucleotide
chains are the same as those of the complementary reversed chains. Up to now, this
hypothesis has only been observed empirically and there is currently no explanation for its
presence in DNA strands. Here we argue that CSPR is a probabilistic consequence of the
reverse complementarity between paired strands, because the Gibbs distribution associated
with the chemical energy between the bonds satisfies CSPR. We develop a statistical test to
study the validity of CSPR under the Gibbsian assumption and we apply it to a large set of
bacterial genomes taken from the GenBank repository. | es_CL |
| Patrocinador | dc.description.sponsorship | Center for Mathematical Modeling (CMM) Basal
CONICYT Program PFB 03 | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Springer | es_CL |
| Keywords | dc.subject | Reverse complementary relation | es_CL |
| Título | dc.title | A Gibbs Approach to Chargaff’s Second Parity Rule | es_CL |
| Document type | dc.type | Artículo de revista | |
