Author | dc.contributor.author | Díaz Véliz, Gabriela | es_CL |
Author | dc.contributor.author | Mora Gutiérrez, Sergio | es_CL |
Author | dc.contributor.author | Gómez, Patricia | es_CL |
Author | dc.contributor.author | Dossi, María Teresa | es_CL |
Author | dc.contributor.author | Montiel, Juan | es_CL |
Author | dc.contributor.author | Arriagada Abarzúa, Christian | es_CL |
Author | dc.contributor.author | Aboitiz Domínguez, Francisco Javier | es_CL |
Author | dc.contributor.author | Segura Aguilar, Juan | |
Admission date | dc.date.accessioned | 2007-04-18T16:12:49Z | |
Available date | dc.date.available | 2007-04-18T16:12:49Z | |
Publication date | dc.date.issued | 2004-02 | |
Cita de ítem | dc.identifier.citation | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 77 (2): 245-251 FEB 2004 | en |
Identifier | dc.identifier.issn | 0091-3057 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/127093 | |
Abstract | dc.description.abstract | The purpose of this study was to evaluate the contribution of DT-diaphorase inhibition to in vivo neurodegenerative effects of dopamine (DA) oxidation to the corresponding o-quinones. The neurotoxicity to nigrostriatal DA neurons was induced by injection of manganese pyrophosphate (Mn3+) complex as a prooxidizing agent alone or together with the DT-diaphorase inhibitor dicumarol into the right rat substantia nigra. The behavioral effects were compared with those induced after selective lesions of dopaminergic neurons with 6-hydroxydopamine (6-OHDA). Intranigral injection of Mn3+ and Mn3+ plus dicumarol produced significant impairment in motor behavior compared with control animals. However, the effect seen in the Mn3+ plus dicumarol injected group was significantly more severe than that observed in the Mn3+ alone injected group. In motor activity and rearing behavior, the simultaneous injection of Mn3+ plus dicumarol produced a 6-OHDA-like impairment. Similar effects were observed in the acquisition of a conditioned avoidance response (CAR). Dicumarol significantly impaired avoidance conditioning although without affecting the motor behavior. The behavioral effects were correlated to the extent of striatal tyrosine hydroxylase (TH)-positive fiber loss. Rats receiving unilateral intranigral Mn3+ and Mn3+ plus dicumarol injections exhibited a significant reduction in nigrostriatal TH-positive fiber density in medial forebrain bundle compared with the contralateral noninjected side. In conclusion, this study provides evidence that the neurotoxicity of Mn3+ in vivo is potentiated by DT-diaphorase inhibition, suggesting that this enzyme could play a neuroprotective role in the nigrostriatal DA systems. | en |
Lenguage | dc.language.iso | en | en |
Publisher | dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en |
Keywords | dc.subject | ONE-ELECTRON REDUCTION | en |
Título | dc.title | Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor | en |
Document type | dc.type | Artículo de revista | |