| Author | dc.contributor.author | Artigas A., Carmen Gloria | |
| Author | dc.contributor.author | Cabrera Contreras, María Elena | es_CL |
| Author | dc.contributor.author | Melo A., Angélica | es_CL |
| Author | dc.contributor.author | Páez F., Eduardo | es_CL |
| Author | dc.contributor.author | Arriagada M., Mónica | es_CL |
| Author | dc.contributor.author | Astete A., Carmen | es_CL |
| Author | dc.contributor.author | Roa E., Iván | es_CL |
| Author | dc.contributor.author | Roa S., Juan Carlos | es_CL |
| Admission date | dc.date.accessioned | 2008-11-27T15:19:35Z | |
| Available date | dc.date.available | 2008-11-27T15:19:35Z | |
| Publication date | dc.date.issued | 2006 | |
| Cita de ítem | dc.identifier.citation | Rev Méd Chile 2006; 134: 1367-1376 | en |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/127567 | |
| Abstract | dc.description.abstract | Background: t(12;21) (p12;q22) and t(9;22) (q34;q11)
translocations have prognostic significance in acute lymphoblastic leukemia (ALL). The fusion genes
TEL/AML1 y BCR/ABL, generated by these translocations, can be easily detected using molecular
biology technique. Aim: To study the frequency of TEL/AML1 y BCR/ABL fusion genes in children
with ALL. Material and methods: Fifity six children with ALL (age range 1 month- 14 years) were
studied, thirty eight from our Temuco Hospital and 18 from the Metropolitan Region. TEL/AML1 y
BCR/ABL fusion genes were detected in bone marrow samples using a reverse transcriptase nested
polymerase chain reaction (RT-PCR). Results: TEL/AML 1 and BCR/ABL fusion gene transcripts
were detected in 13 (23%) and 2 (4%) children, respectively. No differences in survival were
observed between children with positive or negative transcripts for TEL/AML1 fusion gene. However,
those positive for BCR/ABL fusion gene, had a significantly lower survival. Conclusions: The
frequency of TEL/AML1 and BCR/ABL fusion gene transcripts in these children with ALL is similar to
that described by other authors. | en |
| Patrocinador | dc.description.sponsorship | Trabajo financiado por la Universidad de La Frontera, a través del Proyecto DIUFRO
#2121. | en |
| Lenguage | dc.language.iso | es | en |
| Keywords | dc.subject | Fusion proteins, BCR-ABL | en |
| Título | dc.title | Frecuencia de los genes de fusión TEL/AML1 y BCR/ABL en pacientes pediátricos con leucemia linfoblástica aguda | en |
| Title in another language | dc.title.alternative | Frequency of TEL/AML1 and BCR/ABL fusion genes in children with acute lymphoblastic leukemia | en |
| Document type | dc.type | Artículo de revista | |
