Author | dc.contributor.author | Román, Rossana | |
Author | dc.contributor.author | Iñíguez Vila, Germán | es_CL |
Author | dc.contributor.author | Salazar C., Teresa | es_CL |
Author | dc.contributor.author | Avila, Alejandra | es_CL |
Author | dc.contributor.author | Barrera P., Alvaro | es_CL |
Author | dc.contributor.author | Fuentes G., Ariel | es_CL |
Author | dc.contributor.author | Mericq, Verónica | es_CL |
Author | dc.contributor.author | Gunn, Ronald D. | es_CL |
Author | dc.contributor.author | Cassorla Goluboff, Fernando | es_CL |
Admission date | dc.date.accessioned | 2008-12-02T15:14:17Z | |
Available date | dc.date.available | 2008-12-02T15:14:17Z | |
Publication date | dc.date.issued | 2006 | |
Cita de ítem | dc.identifier.citation | Rev Méd Chile 2006; 134: 21-30 | en |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/127604 | |
Abstract | dc.description.abstract | Background: The lack of catch up growth (CUG) in small for
gestational age (SGA) children may be related to a reduced sensitivity to insulin growth factor 1
(IGF-I). Aim: To assess the sensitivity to IGF-I in small for gestational age children, measuring
basal and post IGF-I nocturnal profile of growth hormone (GH). Patients and methods: We
studied 34 prepubertal SGA children aged 4 to 11 years. Twenty three had CUG and 11 did not
have CUG. As an IGF-I sensitivity test, nocturnal GH levels were measured every 20 minutes
from 23:00 h to 07:00 h, both under baseline conditions and after the administration of a
subcutaneous bolus of 1 mg/kg/body weight of the IGF-I + IGFBP-3 complex (Somatokine®).
Results: At the time of the study, the Z scores for height among children with and without CUG
were -1.55 ± 0.22 and -3.24 ± 0.28, respectively (p <0.0001). There were no statistical
differences between CUG + vs CUG- patients in mean basal GH (6.6 ± 0.5 and 5.6 ± 0.6 ng/ml,
respectively). After Somatokine® administration, mean GH, and the mean GH area under the
curve (AUC) decreased significantly in both groups. However, mean overnight GH AUC
decreased in all SGA children with CUG, after Somatokine® administration, whereas 3 out of
11 SGA children without CUG had an increase in their mean GH AUC in response to
Somatokine®. Conclusions: These findings suggest that pituitary sensitivity to IGF-I may be
decreased in some SGA children without CUG. | en |
Patrocinador | dc.description.sponsorship | Trabajo financiado por proyecto Fondecyt #1020965. | en |
Lenguage | dc.language.iso | es | en |
Keywords | dc.subject | Infant, small for gestational age | en |
Título | dc.title | Sensibilidad a IGF-I en niños pequeños para la edad gestacional | en |
Title in another language | dc.title.alternative | IGF-I sensitivity in small for gestational age children | en |
Document type | dc.type | Artículo de revista | |