Author | dc.contributor.author | Carrasco Álvarez, Ximena | es_CL |
Author | dc.contributor.author | Rothhammer Achondo, Paula | es_CL |
Author | dc.contributor.author | Moraga Vergara, Mauricio | es_CL |
Author | dc.contributor.author | Henríquez B., Hugo | es_CL |
Author | dc.contributor.author | Chakraborty, Ranajit | es_CL |
Author | dc.contributor.author | Aboitiz Domínguez, Francisco Javier | es_CL |
Author | dc.contributor.author | Rothhammer Engel, Francisco | |
Admission date | dc.date.accessioned | 2008-12-16T11:06:42Z | |
Available date | dc.date.available | 2008-12-16T11:06:42Z | |
Publication date | dc.date.issued | 2006-01-05 | |
Cita de ítem | dc.identifier.citation | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Volume: 141B Issue: 1 Pages: 51-54 Published: JAN 5 2006 | en |
Identifier | dc.identifier.issn | 1552-4841 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/127654 | |
Abstract | dc.description.abstract | Attention-deficit/hyperactivity disorder, ADHD [MIM 126452], is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness, and/or inattentiveness. As part of an ongoing study of AMID, we carried out a family-based discordant sib-pair analysis to detect possible associations between dopamine receptor D4 (DRD4) and dopamine transporter 1 (DAT1) polymorphisms and ADHD in Chilean families. Both loci individually classified as homozygotes or heterozygotes for the DRD4 7-repeat and DAT1 10-repeat alleles, did not exhibit genotype frequency differences between affected children and their healthy siblings (Fisher's exact test P > 0.25 in both cases). However, the simultaneous presence of both DRD4 7-repeat heterozygosity and DAT1 10 allele homozygosity were significantly higher (34.6%) in cases (26), compared with their unaffected siblings (25) (4%; Fisher's exact test P = 0.0096; odds-ratio, OR = 12.71). Increased density of dopamine transporter in ADHD brains, along with abundance of 7-repeat D4 receptors in prefrontal cortex, which is impaired in ADHD patients, make the observed gene-gene interaction worthy of further incisive studies. | en |
Lenguage | dc.language.iso | en | en |
Publisher | dc.publisher | WILEY-LISS | en |
Keywords | dc.subject | DEFICIT HYPERACTIVITY DISORDER | en |
Título | dc.title | Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families | en |
Document type | dc.type | Artículo de revista | |