Author | dc.contributor.author | Mancilla Asencio, Carla | es_CL |
Author | dc.contributor.author | Madrid Silva, Ana | es_CL |
Author | dc.contributor.author | Valenzuela Escobar, Jorge | es_CL |
Author | dc.contributor.author | Morales Barria, Antonio | es_CL |
Author | dc.contributor.author | Hurtado Heim, Carmen | es_CL |
Author | dc.contributor.author | Smok Sahid, Gladys | es_CL |
Author | dc.contributor.author | Ledezma R., Rodrigo | es_CL |
Author | dc.contributor.author | Castillo Montecinos, Iván | es_CL |
Author | dc.contributor.author | Rivas Q., Mauricio | es_CL |
Author | dc.contributor.author | Brahm Barril, Javier | |
Admission date | dc.date.accessioned | 2009-05-15T16:12:05Z | |
Available date | dc.date.available | 2009-05-15T16:12:05Z | |
Publication date | dc.date.issued | 2005-11 | |
Cita de ítem | dc.identifier.citation | Revista médica de Chile v.133, n.11, nov. 2005 | en |
Identifier | dc.identifier.issn | 0034-9887 versión impresa | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/127859 | |
Abstract | dc.description.abstract | The prevalence of celiac disease (CD) is unknown in
Chile. We have recently noted a rise in the number of cases diagnosed among adults. Aim: To
describe the clinical characteristics of a group of adult celiac patients. Patients and methods:
Clinical data of patients older than 15 years with positive antitransglutaminase or
antiendomysial autoantibodies and a duodenal biopsy characteristic of CD were retrospectively
reviewed. Age at diagnosis, symptoms and signs and laboratory, endoscopic and histological
findings, were analyzed. Results: Thirty seven patients (28 women), were studied. Median age
at diagnosis was 41 years (range 15-69). Main symptoms and signs were diarrhea (78%), weight
loss (38%) and abdominal pain (38%). Anemia was found in 49%, elevation of ESR in 57%,
elevation of alkaline phosphatases in 54%, elevation of aspartate aminotransferase in 38% and a
rise in alanine aminotransferase in 27%. Antiendomysial antibodies were positive in 17/22
(77%) and antitransglutaminase in 19/22 (86%) patients. Endoscopic findings were suggestive of
CD in 47% of cases and duodenal biopsy showed intestinal villi atrophy in 34 (92%) patients.
The three patients with normal histology had positive serology and a good response to gluten free
diet. Conclusions: CD should be considered in the differential diagnosis of patients with
unespecific digestive symptons, even when they present late in adult life. Serologic markers are a
good diagnostic tool. A normal duodenal pathology does not exclude the diagnosis, if other
diagnostic features are present. | en |
Lenguage | dc.language.iso | es | en |
Publisher | dc.publisher | Sociedad Médica de Santiago | en |
Keywords | dc.subject | Celiac disease | en |
Título | dc.title | Enfermedad celíaca del adulto:Experiencia clínica | en |
Document type | dc.type | Artículo de revista | |