| Author | dc.contributor.author | Orellana Bown, Myriam | es_CL |
| Author | dc.contributor.author | Guajardo Tobar, Viviana | |
| Admission date | dc.date.accessioned | 2009-06-18T11:44:53Z | |
| Available date | dc.date.available | 2009-06-18T11:44:53Z | |
| Publication date | dc.date.issued | 2004-01 | |
| Cita de ítem | dc.identifier.citation | REVISTA MEDICA DE CHILE, V.: 132, issue: 1, p.: 85-94, JAN 2004. | en |
| Identifier | dc.identifier.issn | 0034-9887 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/127973 | |
| Abstract | dc.description.abstract | Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2. The diversity of reactions catalyzed and its extensive substrate specificity render CYP enzymes
as one of the most versatile known catalysts. Individual members of the CYP superfamily are expressed in almost every cell type in the body. As compared to hepatic enzymes, the regulation
of human extrahepatic CYPs has not been so well studied. In general, the levels of some
hepatic CYP enzymes are depressed by diseases, causing potential and documented impairment of drug clearence and clinical drug toxicity. However, modulation of CYPs is enzyme selective and this selectivity differs in different diseases. This article reviews some basic concepts about
CYP and its regulation in some disease states such as hypertension, diabetes, obesity and hepatic, infectious and inflammatory diseases | en |
| Patrocinador | dc.description.sponsorship | Financiamiento: Proyecto Fondecyt 1011057. | en |
| Lenguage | dc.language.iso | es | en |
| Publisher | dc.publisher | SOC MEDICA SANTIAGO | en |
| Keywords | dc.subject | Cytochrome P450 | en |
| Título | dc.title | Actividad del citocromo P450 y su alteración en diversas patologías | en |
| Document type | dc.type | Artículo de revista | |
