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Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox

Authordc.contributor.authorFaúndez, Mario
Authordc.contributor.authorLópez Muñoz, Rodrigoes_CL
Authordc.contributor.authorTorres, Gloriaes_CL
Authordc.contributor.authorMorello Casté, Antonioes_CL
Authordc.contributor.authorFerreira, Jorgees_CL
Authordc.contributor.authorKemmerling Weis, Ulrikees_CL
Authordc.contributor.authorOrellana Bown, Myriames_CL
Authordc.contributor.authorMaya Arango, Juanes_CL
Admission datedc.date.accessioned2010-01-20T17:09:12Z
Available datedc.date.available2010-01-20T17:09:12Z
Publication datedc.date.issued2008
Cita de ítemdc.identifier.citationAGENTS AND CHEMOTHERAPY Volume: 52 Issue: 5 Pages: 1837-1839 Published: MAY 2008en_US
Identifierdc.identifier.issn0066-4804
Identifierdc.identifier.other10.1128/AAC.01454-07
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/128273
Abstractdc.description.abstractL-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused an increase in the survival rate in comparison to the rates with treatment with each drug alone.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherAMER SOC MICROBIOLOGYen_US
Keywordsdc.subjectGLUTATHIONE SYNTHESISen_US
Títulodc.titleButhionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimoxen_US
Document typedc.typeArtículo de revista


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