Diminished Acute Phase Response and Increased Hepatic Inflammation of Aged Rats in Response to Intraperitoneal Injection of Lipopolysaccharide
Author | dc.contributor.author | Gómez, Christian | |
Author | dc.contributor.author | Acuña Castillo, Claudio | es_CL |
Author | dc.contributor.author | Pérez Núñez, Claudio | es_CL |
Author | dc.contributor.author | Leiva Salcedo, Elías | es_CL |
Author | dc.contributor.author | Riquelme, Denise | es_CL |
Author | dc.contributor.author | Ordenes, Gamaliel | es_CL |
Author | dc.contributor.author | Oshima, Kiyoko | es_CL |
Author | dc.contributor.author | Aravena, Mauricio | es_CL |
Author | dc.contributor.author | Pérez, Viviana I. | es_CL |
Author | dc.contributor.author | Nishimura, Sumiyo | es_CL |
Author | dc.contributor.author | Sabaj Diez, Valeria | es_CL |
Author | dc.contributor.author | Walter, Robin Ann | es_CL |
Author | dc.contributor.author | Sierra, Felipe | es_CL |
Admission date | dc.date.accessioned | 2010-01-25T15:21:58Z | |
Available date | dc.date.available | 2010-01-25T15:21:58Z | |
Publication date | dc.date.issued | 2008-12 | |
Cita de ítem | dc.identifier.citation | JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES Volume: 63 Issue: 12 Pages: 1299-1306 Published: DEC 2008 | en_US |
Identifier | dc.identifier.issn | 1079-5006 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/128300 | |
Abstract | dc.description.abstract | Aging is associated with a deterioration of the acute phase response to inflammatory challenges. However, the nature of these defects remains poorly defined. We analyzed the hepatic inflammatory response after intraperitoneal administration of lipopolysaccharide (LPS) given to Fisher 344 rats aged 6, 15, and 22-23 months. Induction of the acute phase proteins (APPs), haptoglobin, a-I-acid glycoprotein, and T-kininogen was reduced and/or retarded with aging. Initial induction of interleukin-6 in aged rats was normal, but the later response was increased relative to younger counterparts. An exacerbated hepatic injury was observed in aged rats receiving LPS, as evidenced by the presence of multiple microabscesses in portal tracts, confluent necrosis, higher nentrophil accumulation, and elevated serum levels of alanine aminotransferase, relative to younger animals. Our results suggest that aged rats displayed a reduced expression of APPS and increased hepatic injury in response to the inflammatory insult. | en_US |
Patrocinador | dc.description.sponsorship | Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) 101061 2000038 2010071 Fondo de Financiamiento de Centros de Excelencia en Investigacion (FONDAP) 15010006 National Institutes of Health/National Institute on Aging AG13902 | en_US |
Lenguage | dc.language.iso | en | en_US |
Publisher | dc.publisher | GERONTOLOGICAL SOC AMER | en_US |
Keywords | dc.subject | GENE-EXPRESSION | en_US |
Título | dc.title | Diminished Acute Phase Response and Increased Hepatic Inflammation of Aged Rats in Response to Intraperitoneal Injection of Lipopolysaccharide | en_US |
Document type | dc.type | Artículo de revista |
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