Author | dc.contributor.author | Simola, Nicola | |
Author | dc.contributor.author | Bustamante, Diego | es_CL |
Author | dc.contributor.author | Pinna, Annalisa | es_CL |
Author | dc.contributor.author | Pontis, Silvia | es_CL |
Author | dc.contributor.author | Morales Retamales, Paola | es_CL |
Author | dc.contributor.author | Morelli, Micaela | es_CL |
Author | dc.contributor.author | Herrera-Marschitz Muller, Mario | es_CL |
Admission date | dc.date.accessioned | 2010-01-28T18:19:14Z | |
Available date | dc.date.available | 2010-01-28T18:19:14Z | |
Publication date | dc.date.issued | 2008-03 | |
Cita de ítem | dc.identifier.citation | EXPERIMENTAL BRAIN RESEARCH, Volume: 185, Issue: 4, Pages: 595-601, 2008 | en_US |
Identifier | dc.identifier.issn | 0014-4819 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/128401 | |
Abstract | dc.description.abstract | A large body of clinical evidence suggests a
possible association between perinatal asphyxia and the
onset of early, as well as long-term, neurological and psychiatric
disorders including cognitive deWcits. The present
study investigated cognitive and motor function modiWcations
in a well characterized and clinically relevant experimental
rat model of human perinatal asphyxia. The results
reported here show that adult rats exposed to a single
(20 min) asphyctic episode at delivery displayed: (a) a deWcit
in non-spatial memory, assessed in a novel object recognition
task; (b) an impaired motor coordination, measured
by the rotarod test. On the other hand, gross motor activity
and spatial memory, evaluated in both the Y maze and the
Barnes maze, were not aVected by perinatal asphyxia. The
results of this study provide further insights into the longterm
eVects of perinatal asphyxia on neurobehavioural
functions. | en_US |
Patrocinador | dc.description.sponsorship | This study was supported by funds from
“Regione Autonoma della Sardegna” LR 19/96 (2003) for ScientiWc
Cooperation between Italy and Chile (Italy) and by funds from
Fondecyt and ICBM-Enlace grants (Chile). | en_US |
Lenguage | dc.language.iso | en | en_US |
Publisher | dc.publisher | SPRINGER | en_US |
Keywords | dc.subject | Asphyctic insult | en_US |
Título | dc.title | Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats | en_US |
Document type | dc.type | Artículo de revista | |