Author | dc.contributor.author | Lanas Montecinos, Alejandra | |
Author | dc.contributor.author | Letelier, Carolina | es_CL |
Author | dc.contributor.author | Caamaño, Edgardo | es_CL |
Author | dc.contributor.author | Massardo Vega, Lucía | es_CL |
Author | dc.contributor.author | González Espinoza, Patricio | es_CL |
Author | dc.contributor.author | Araya, A. Verónica | es_CL |
Admission date | dc.date.accessioned | 2010-06-21T20:23:36Z | |
Available date | dc.date.available | 2010-06-21T20:23:36Z | |
Publication date | dc.date.issued | 2010 | |
Cita de ítem | dc.identifier.citation | Rev Med Chile 2010; 138: 15-21 | en_US |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/128617 | |
Abstract | dc.description.abstract | Background: Anti-thyroid peroxidase antibodies have a pathogenic role in Hashimoto
thyroiditis. Between 10 and 19% of individuals without thyroid disease have positive titers of these antibodies. Aim: To study the frequency of positive titers of anti-thyroid peroxidase antibodies in healthy individuals. Material and Methods: A blood sample, to measure anti-thyroid peroxidase antibodies and thyroid stimulating hormone (TSH) by chemoluminiscense assay, was obtained from 67 women and 62 men aged 45 ± 14 years, without a personal or familial history of thyroid diseases and normal thyroid palpation. The cutoff point of the manufacturer to consider positive a titer of anti-thyroid peroxidase antibodies was set at 35 IU/ml. Results: Twenty eight women and 28 men had positive antibody titers (43% of the sample). Subjects in the upper tercile of anti-thyroid peroxidase antibody titers had a higher TSH than those in the second tercile, although within normal limits (1.73 ± 0.74 and 1.37 ± 0.59 mIU/L, respectively p = 0.02) Conclusions: Forty three percent of the studied subjects without personal or familial history of thyroid diseases, had positive titers of anti-thyroid peroxidase antibodies. Further prospective studies should evaluate whether this observation discloses an increase in thyroid autoimmune disease in a population with increased iodine intake. | en_US |
Lenguage | dc.language.iso | es | en_US |
Keywords | dc.subject | Antibodies | en_US |
Título | dc.title | Alta frecuencia de anticuerpos anti-tiroperoxidasa (ATPO) positivos en sujetos adultos, sin patología tiroidea conocida, de Santiago de Chile | en_US |
Title in another language | dc.title.alternative | Frequency of positive anti thyroid peroxidase antibody titers among normal individuals | en_US |
Document type | dc.type | Artículo de revista | |