| Abstract | dc.description.abstract | Context: We previously demonstrated that low birth weight (BW) infant girls show increased
serum anti-Mu¨ llerianhormone(AMH)concentrationsandpoststimulated estradiol levels compared to
normal-BW infants, suggesting an altered follicular development. However, the impact of highBWon
reproductive function is less known.
Objective: To evaluate the effect of BW on AMH, we determined the concentrations of this
hormone in low-BW, normal-BW, and high-BW female infants during the first 3 months of life.
Design: Twenty-seven low-BW, 29 normal-BW, and 28 high-BW infant girls were studied. We
measured serum gonadotropins, steroid hormones, AMH, glucose, insulin, free fatty acids, IGF-I,
and adiponectin in a fasting blood sample. In addition, in a subgroup of normal-BW (n 23) and
high-BW infants (n 10), a GnRH analog leuprolide acetate test was performed.
Results: Serum concentrations of AMH were higher in low-BW and high-BW infants compared to
normal-BW infants (P 0.028 and 0.022, respectively). In addition, in high-BW infants, adiponectin
concentrations were lower (P 0.018), and poststimulated FSH and estradiol levels were higher
compared to normal-BW infants (P 0.024 and 0.047, respectively).
Conclusions: Serum AMH and poststimulated estradiol concentrations are increased in low-BW and
high-BW female infants, suggesting that these girls may show evidence of an altered follicular development.
However, the increased poststimulated FSH levels and low adiponectin concentrations observed
in high-BW infants suggest that ovarian function is perturbed through a different mechanism
from that in low-BW infants. | en_US |
