Author | dc.contributor.author | Amigo Cartagena, Hugo | es_CL |
Author | dc.contributor.author | Bustos Ramírez, Patricia | es_CL |
Author | dc.contributor.author | Alvarado, María Elena | es_CL |
Author | dc.contributor.author | Barbieri, Marco | es_CL |
Author | dc.contributor.author | Bettiol, Heloisa | es_CL |
Author | dc.contributor.author | Silva, Antônio Augusto M. da | |
Author | dc.contributor.author | Rona, Roberto J. | es_CL |
Admission date | dc.date.accessioned | 2010-11-19T17:05:40Z | |
Available date | dc.date.available | 2010-11-19T17:05:40Z | |
Publication date | dc.date.issued | 2010 | |
Cita de ítem | dc.identifier.citation | J Epidemiol Community Health (2010) | en_US |
Identifier | dc.identifier.other | doi:10.1136/jech.2008.078345 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/128775 | |
Abstract | dc.description.abstract | Background The relationship between birth weight and
plasma lipoproteins is inconsistent.
Aims To assess the association between birth weight
and (1) body mass index (BMI) at birth and (2)
lipoproteins in young adults, and also to explore the
possible effect of current obesity as a possible effect
modifier.
Methods Two prospective studies based on
representative samples of subjects born in the 1970s
were carried out in Ribeira˜o Preto, Brazil (n¼2063) and
Limache, Chile (n¼999). The surveys were carried out
between 2001 and 2004.
Results Mean birth weights were 3267 g and 3177 g
and mean adult BMIs were 24.3 kg/m2 and 25.8 kg/m2
in the Brazilian and Chilean samples, respectively. Total
adult cholesterol was 4.57 mmol/l in Chileans,
0.26 mmol/l higher than in Brazilians (p<0.001). The
main finding was an interaction between adult obesity
(BMI 30 or over) and birth weight and also BMI at birth
and low-density lipoprotein (LDL) and total cholesterol. A
birth-weight increment of 1 kg was associated with
a decrease in total cholesterol ( 0.374 mmol/l, 95% CI
0.567 to 0.181) and LDL ( 0.304 mmol/l ( 0.479
to 0.129) in obese participants only. These
associations persisted after allowing for gestational age
in a smaller sample. This finding was consistent in
separate analyses in the Brazilian and Chilean samples.
No associations were found in relation to high-density
lipoprotein and triglyceride concentrations.
Conclusion The results suggest that those who were of
low birth weight and are obese are more likely to have
high cholesterol and LDL concentrations. Thus preventing
obesity may be especially rewarding in subjects with
a low birth weight. | en_US |
Patrocinador | dc.description.sponsorship | Funding for the Chilean study was provided by the National Fund for
Scientific and Technological Development (FONDECYT), grant 1010572. The study in Brazil was supported by
Fundac¸ao de Amparo a` Pesquisa do Estado de Saˆo Paulo (FAPESP), grant
2000/09508-7 | en_US |
Lenguage | dc.language.iso | en | en_US |
Título | dc.title | Size at birth and lipoprotein concentrations in adulthood: two prospective studies in Latin American cities | en_US |
Document type | dc.type | Artículo de revista | |