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Authordc.contributor.authorCastro, Pablo 
Authordc.contributor.authorGabrielli, Luigi A. es_CL
Authordc.contributor.authorVerdejo, Hugo es_CL
Authordc.contributor.authorGreig, Douglas es_CL
Authordc.contributor.authorMellado, Rose Marie es_CL
Authordc.contributor.authorConcepción, Roberto es_CL
Authordc.contributor.authorSepúlveda Morales, Luis es_CL
Authordc.contributor.authorVukasovic Ramírez, José Luis es_CL
Authordc.contributor.authorGarcía Nannig, Lorena es_CL
Authordc.contributor.authorPizarro, Marcela es_CL
Authordc.contributor.authorPivet, Deisy es_CL
Authordc.contributor.authorCarrillo, Constanza es_CL
Authordc.contributor.authorTapia, Fabiola es_CL
Authordc.contributor.authorNavarro, Mario es_CL
Authordc.contributor.authorTroncoso, Rodrigo es_CL
Authordc.contributor.authorBaraona, Fernando es_CL
Authordc.contributor.authorLlevaneras, Silvana es_CL
Authordc.contributor.authorHernández, Claudia es_CL
Authordc.contributor.authorGodoy, Iván es_CL
Authordc.contributor.authorJalil Milad, Jorge es_CL
Authordc.contributor.authorQuintana, Juan Carlos es_CL
Authordc.contributor.authorOrellana, Pilar es_CL
Authordc.contributor.authorChiong Lay, Mario es_CL
Authordc.contributor.authorLavandero González, Sergioes_CL
Admission datedc.date.accessioned2010-11-22T12:57:09Z
Available datedc.date.available2010-11-22T12:57:09Z
Publication datedc.date.issued2010-08
Cita de ítemdc.identifier.citationREVISTA MEDICA DE CHILE Volume: 138 Issue: 8 Pages: 1028-1039 Published: AUG 2010en_US
Identifierdc.identifier.issn0034-9887
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/128778
Abstractdc.description.abstractIt is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.en_US
Lenguagedc.language.isoesen_US
Publisherdc.publisherSOC MEDICA SANTIAGOen_US
Keywordsdc.subjectDrug therapyen_US
Títulodc.titleMetabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíacaen_US
Title in another languagedc.title.alternativeHeart energy metabolism and its role in the treatment of heart failureen_US
Document typedc.typeArtículo de revistaen_US


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