Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile
Author | dc.contributor.author | Cabrera Contreras, María Elena | es_CL |
Author | dc.contributor.author | Silva, Guillermo | es_CL |
Author | dc.contributor.author | Soto, Andrés | es_CL |
Author | dc.contributor.author | Rosello, Rodrigo | es_CL |
Author | dc.contributor.author | Castro, Constanza | es_CL |
Author | dc.contributor.author | Martínez, Virginia | es_CL |
Author | dc.contributor.author | Ballesteros, Juan | es_CL |
Author | dc.contributor.author | Blamey, Rodrigo | |
Author | dc.contributor.author | Garreaud, Claudia | es_CL |
Admission date | dc.date.accessioned | 2012-05-25T15:26:09Z | |
Available date | dc.date.available | 2012-05-25T15:26:09Z | |
Publication date | dc.date.issued | 2012-02 | |
Cita de ítem | dc.identifier.citation | REVISTA MEDICA DE CHILE Volume: 140 Issue: 2 Pages: 243-250 Published: FEB 2012 | es_CL |
Identifier | dc.identifier.issn | 0034-9887 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/128959 | |
Abstract | dc.description.abstract | Background: Cancer is the third cause of death in patients infected with human immunodeficiency virus (HIV) and lymphoma is the most common type. Aim: To describe the clinical characteristics, histology, risk factors and prognosis of these patients, in a Chilean public hospital in Chile. Material and Methods: Records of 55 patients (45 males) aged between 23 and 67 years with lymphoma and HIV positive serology, diagnosed between 1992-2008, were reviewed. Results: Six patients (11%) had Hodgkin lymphoma (HL) and the rest, non-Hodgkin lymphoma (NHL). B-cell phenotype constituted 83.7% of NHL cases. The most common subtypes of all the lymphoma were diffuse large B cell lymphoma in 24 cases (43.6%), Burkitt lymphoma in 12 cases (21.8%), and plasmablastic lymphoma in 5 cases (9.1%). Thirty five patients (64%) underwent curative intended chemotherapy (CT) concomitantly with highly active antiretroviral therapy (HAART). Three year survival of the whole cohort was 27%. By multivariate analysis, the most important prognostic factors for long term survival, were complete responses to CT, (p < 0.01) and a low international prognostic index (IPI) score for NHL, (p = 0.01). HAART, histologic subtype and CD4 lymphocyte count at diagnosis, did not influence survival. Conclusions: The most important prognostic factors for HIV patients with lymphoma, were achieving CR with CT and low IPI score. Prognosis remains poor, even with HAART therapy. | es_CL |
Lenguage | dc.language.iso | es | es_CL |
Publisher | dc.publisher | SOC MEDICA SANTIAGO | es_CL |
Keywords | dc.subject | antiretroviral therapy | es_CL |
Título | dc.title | Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile | es_CL |
Title in another language | dc.title.alternative | HIV-related lymphoma in a public hospital in Chile. Analysis of 55 cases | es_CL |
Document type | dc.type | Artículo de revista |
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