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Authordc.contributor.authorMaliqueo Yevilao, Manuel 
Authordc.contributor.authorGalgani Fuentes, José es_CL
Authordc.contributor.authorPérez Bravo, Francisco es_CL
Authordc.contributor.authorEchiburú López, Bárbara es_CL
Authordc.contributor.authorLadrón de Guevara, Amanda es_CL
Authordc.contributor.authorCrisosto King, Nicolás es_CL
Authordc.contributor.authorSir Petermann, Lidia es_CL
Admission datedc.date.accessioned2012-06-18T20:03:21Z
Available datedc.date.available2012-06-18T20:03:21Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationEuropean Journal of Obstetrics & Gynecology and Reproductive Biology 161 (2012) 56–61es_CL
Identifierdc.identifier.otherdoi:10.1016/j.ejogrb.2011.12.012
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/128976
General notedc.descriptionArtículo de publicación ISIes_CL
Abstractdc.description.abstractObjective: To evaluate in a cross-sectional study adiponectin and leptin levels in prepubertal and pubertal daughters of women with PCOS and their relationship to insulin sensitivity and reproductive features. Study design: We studied 92 daughters of PCOS women (PCOSd) and 76 daughters of control women (Cd) matched by age and body mass index SD scores and distributed according to breast Tanner stage: prepuberty (Tanner 1), early puberty (Tanner 2–3) or late puberty (Tanner 4–5). In all girls an oral glucose tolerance test was performed. Leptin, adiponectin, sex steroids, SHBG, glucose, insulin and lipid profile were determined. Leptin–adiponectin ratio, free androgen index and insulin sensitivity (HOMA-IR and ISI composite) were then calculated. Results: Prepubertal PCOSd showed lower serum adiponectin compared to Cd (p = 0.028), whereas during puberty no differences were observed between the groups. Leptin concentrations were similar in both groups in all Tanner stages. In addition, in PCOSd during early puberty, adiponectin showed a negative correlation with testosterone and leptin showed a negative correlation with ISI composite, which were independent of BMI SDS (r = 0.39; p = 0.02 and r = 0.42; p = 0.01). Conclusion: These observations suggest that during the prepubertal period PCOSd exhibit abnormal adiponectin levels, independently of BMI. Moreover, leptin and adiponectin may be related to metabolic and reproductive abnormalities observed in PCOSd during the early stages of sexual development.es_CL
Patrocinadordc.description.sponsorshipThis study was supported by the National Fund for Scientific and Technological Research; Fondecyt; grant no.: N 1071007 and the Alexander Von Humboldt Foundation.es_CL
Lenguagedc.language.isoenes_CL
Publisherdc.publisherElsevieres_CL
Keywordsdc.subjectPolycystic ovary syndromees_CL
Títulodc.titleRelationship of serum adipocyte-derived proteins with insulin sensitivity and reproductive features in pre-pubertal and pubertal daughters of polycystic ovary syndrome womenes_CL
Document typedc.typeArtículo de revista


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