| Author | dc.contributor.author | Cáceres Lillo, Dante | |
| Author | dc.contributor.author | Werlinger Cruces, Fabiola | |
| Author | dc.contributor.author | Orellana, Magdalena | |
| Author | dc.contributor.author | Jara, Marcelo | |
| Author | dc.contributor.author | Rocha, René | |
| Author | dc.contributor.author | Alvarado, Sergio A. | |
| Author | dc.contributor.author | Quiñones Sepúlveda, Luis | |
| Admission date | dc.date.accessioned | 2013-07-09T16:21:23Z | |
| Available date | dc.date.available | 2013-07-09T16:21:23Z | |
| Publication date | dc.date.issued | 2013-07-09 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/129029 | |
| General note | dc.description | Archives of Environmental & Occupational Health, Vol. 65, No. 3, 2010 | |
| Abstract | dc.description.abstract | Glutathione S-tranferases (GST) are multigenic enzymes that have been associated with
arsenic metabolism. The objective of this study was to evaluate the relationship between polymorphic
variants of GST and urinary concentration of arsenic species in people exposed to lowlevels of arsenic.
A cross-sectional study among 66 nonoccupationally exposed subjects, living in the city of Antofagasta,
Chile. Polymorphic variants were analyzed by polymerase chain reaction (PCR) and arsenic
species was determined by atomic absorption spectrometry. The effect of GST variants on arsenic
concentration was evaluated using univariate and covariate-adjusted regressions. For both GSTT1 and
GSTM1 there were no significant differences in detected arsenic relative species between carriers of
the active and null polymorphic variants. There was nondefinitive evidence that polymorphic variants
of GST play a role in arsenic metabolism in sample of the Chilean subjects studied. | en_US |
| Patrocinador | dc.description.sponsorship | Financial support was provided by FOGARTY N◦ D43TW05746. International
Training and Research In Environmental and Occupational Health
(ITREOH). National Institute of Health, USA, and REIN N◦ 05/02 project
of the Department of Investigation (DI) of the University of Chile | |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | Taylor & Francis | |
| Keywords | dc.subject | arsenic | en_US |
| Keywords | dc.subject | exposure assessment | |
| Título | dc.title | Polymorphism of Glutathione S-Transferase (GST) Variants and Its Effect on Distribution of Urinary Arsenic Species in People Exposed to Low Inorganic Arsenic in Tap Water: An Exploratory Study | en_US |
| Document type | dc.type | Artículo de revista | |
