| Author | dc.contributor.author | Quiñones Sepúlveda, Luis | es_CL |
| Author | dc.contributor.author | Berthou, F. | es_CL |
| Author | dc.contributor.author | Varela Figueroa, Nelson | es_CL |
| Author | dc.contributor.author | Simon, B. | es_CL |
| Author | dc.contributor.author | Gil, Lionel | |
| Author | dc.contributor.author | Lucas, D. | es_CL |
| Admission date | dc.date.accessioned | 2013-07-10T14:55:51Z | |
| Available date | dc.date.available | 2013-07-10T14:55:51Z | |
| Publication date | dc.date.issued | 1999 | |
| Cita de ítem | dc.identifier.citation | Cancer Letters 141 (1999) 167±171 | en_US |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/129038 | |
| General note | dc.description | Artículo de publicación ISI | en_US |
| Abstract | dc.description.abstract | Many investigators have reported an association between genetic polymorphisms of cytochromes P-450 CYP2E1, CYP1A1
or glutathione S-transferase Mu (GSTM1) and susceptibility to lung cancer. However, pronounced interethnic variations have
been described in the frequencies of these polymorphisms, especially between Asians and Caucasians. The present study was
set up to establish CYP2E1 (c1, c2 and C, D), CYP1A1 (m1, m2 and Ile, Val) and GSTM1 (null) allelic frequencies in Chileans
(n 96) who are an admixture of Native Americans and Caucasians (Spaniards). The rare allele frequencies were found to be
0.15 (c2), 0.21 (C), 0.23 (m2), 0.32 (Val) and 0.21 ('null' genotype). These values are signi®cantly higher than those of
Caucasians except for the GSTM1 'null' genotype and suggest differences in susceptibility to lung cancer between both
populations. q1999 Elsevier Science Ireland Ltd. All rights reserved. | en_US |
| Patrocinador | dc.description.sponsorship | This study was supported by grants INCODC,
European Communities ERB-IG 18-CT98-0341,
FONDECYT 2950034 and DID from the University
of Chile, and IREB 96/02 from France. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | Elsevier | en_US |
| Keywords | dc.subject | CYP2E1 | en_US |
| Título | dc.title | Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations | en_US |
| Document type | dc.type | Artículo de revista | |
