The oleic acid esterification of policosanol increases its bioavailability and hypocholesterolemic action in rats
Author
dc.contributor.author
Haim, D.
Author
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Valenzuela, A.
es_CL
Author
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Brañes, M. C.
es_CL
Author
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Fuenzalida, M.
es_CL
Author
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Videla Cabrera, Luis
es_CL
Admission date
dc.date.accessioned
2014-01-07T20:21:12Z
Available date
dc.date.available
2014-01-07T20:21:12Z
Publication date
dc.date.issued
2012-10
Cita de ítem
dc.identifier.citation
Grasas y Aceites, 63 (4), octubre-diciembre, 345-354, 2012 doi: 10.3989/gya.010612
en_US
Identifier
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0017-3495
Identifier
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https://repositorio.uchile.cl/handle/2250/129106
General note
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Artículo de publicación ISI
en_US
Abstract
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Policosanol comprises a mixture of long-chain aliphatic
alcohols from sugarcane wax. More than 50 studies indicate
that policosanol decreases serum cholesterol, while others
failed to reproduce this effect. The objective of this investigation
was to assess the bioavailability of esterified policosanol
and non-esterified policosanol (NEP), in relation to their
hypocholesterolemic effects. Sprague Dawley rats were given
a daily oral dose of 100 mg/kg of NEP, 117 mg kg–1 of butyric
acid esterified policosanol (BAEP), or 164 mg kg–1 of oleic acid
esterified policosanol (OAEP). Policosanol absorption was
evaluated in plasma between 0 and 3 hours after ingestion. To
assess changes in total cholesterol, LDL-cholesterol, HDLcholesterol
and triacylglycerols in plasma and liver 3-hydroxy-
3-methylglutaryl coenzyme A reductase (HMG- CoA red)
phosphorylation, the rats were supplemented with nonesterified
or esterified policosanol for 5 weeks. The results
indicate that policosanol absorption was significantly greater in
OAEP-treated rats than in those subjected to NEP or BAEP
administration. OAEP significantly reduced plasma total and
LDL-cholesterol in rats, in addition to a 5.6-fold increase
(P < 0.05) in the hepatic content of phosphorylated HMG-CoA
red over the control values. In conclusion, esterification of
policosanol with oleic acid enhances policosanol bioavailability,
and significantly improves the serum lipid profile in
normocholesterolemic rats in association with the inactivation
of HMG-CoA red controlling cholesterogenesis
en_US
Patrocinador
dc.description.sponsorship
The work was supported by grant 1090020 from
FONDECYT, Chile. DH was supported by fellowship
TPI-27 from PBCT, Chile.