Zinc as a potential coadjuvant in therapy for type 2 diabetes
Author
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Ruz Ortíz, Manuel
Author
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Carrasco Naranjo, Fernando
es_CL
Author
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Rojas Mondaca, Pamela
es_CL
Author
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Codoceo, Juana
es_CL
Author
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Inostroza Escobar, Jorge
es_CL
Author
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Basfi-fer Obregón, Karen
es_CL
Author
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Valencia Canessa, Alejandra
es_CL
Author
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Vásquez, Karla
es_CL
Author
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Galgani Fuentes, José
es_CL
Author
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Pérez, Alvaro
es_CL
Author
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López, Gloria
es_CL
Author
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Arredondo Olguín, Miguel
es_CL
Author
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Pérez Bravo, Francisco
es_CL
Admission date
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2014-02-04T18:11:47Z
Available date
dc.date.available
2014-02-04T18:11:47Z
Publication date
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2013
Cita de ítem
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Food and Nutrition Bulletin, vol. 34, no. 2
en_US
Identifier
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https://repositorio.uchile.cl/handle/2250/129243
General note
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Artículo de publicación ISI
en_US
Abstract
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Background: Type 2 diabetes is highly prevalent in
populations having high rates of overweight and obesity.
It is a chronic condition responsible for long-term severe
dysfunction of several organs, including the kidneys,
heart, blood vessels, and eyes. Although there are a
number of pharmacologic products in the market to treat
insulin resistance and impaired insulin secretion—the
most prominent features of this disease—interventions
directed at preserving the integrity and function of β-cells
in the long term are less available. The use of some nutrients
with important cellular protective roles that may
lead to a preservation of β-cells has not been fully tested;
among these, zinc may be an interesting candidate.
Objective: To assess the potential of zinc supplementation
as coadjuvant to diabetes therapy.
Methods: This article reviews the available information
on the use of zinc as part of diabetes therapy.
Results: Cellular and animal models provide information
on the insulin mimetic action of zinc, as well as its role
as a regulator of oxidative stress, inflammation, apoptosis,
and insulin secretion. Zinc supplementation studies in
humans are limited, although some positive effects have
been reported; mainly, a modest but significant reduction
in fasting glucose and a trend to decreased glycated
hemoglobin (HbA1c).
Conclusions: Zinc supplementation may have
beneficial effects on glycemic control. Nevertheless,
among the studies considered, the vast majority lasted for
6 months or less, suggesting the importance of conducting
long-duration studies given the characteristics of type 2
diabetes as a chronic disease.